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Riok3 RIO kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361293, updated on 2-Nov-2024

Summary

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Official Symbol
Riok3provided by RGD
Official Full Name
RIO kinase 3provided by RGD
Primary source
RGD:1310833
See related
EnsemblRapid:ENSRNOG00000023376 AllianceGenome:RGD:1310833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable caspase binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to dsDNA; negative regulation of intracellular signal transduction; and positive regulation of interferon-beta production. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Orthologous to human RIOK3 (RIO kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 386.5), Kidney (RPKM 182.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Riok3 in Genome Data Viewer
Location:
18p13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (3602535..3628108)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3327776..3353350)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3565166..3590739)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 241 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134482901 Neighboring gene regulator of MON1-CCZ1 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene AKT interacting protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles. Baumas K, et al. RNA Biol, 2012 Feb. PMID 22418843, Free PMC Article
  2. RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway. Shan J, et al. Mol Cell Biochem, 2009 Dec. PMID 19557502
  3. RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response. Takashima K, et al. Cell Rep, 2015 Apr 14. PMID 25865883
  4. RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production. Feng J, et al. J Virol, 2014 Jul. PMID 24807708, Free PMC Article
  5. The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits. Widmann B, et al. Mol Biol Cell, 2012 Jan. PMID 22072790, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables caspase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to dsDNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to dsRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase RIO3
NP_001101893.1
XP_063133531.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108423.1 → NP_001101893.1  serine/threonine-protein kinase RIO3

    See identical proteins and their annotated locations for NP_001101893.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474073
    UniProtKB/TrEMBL
    A6KNG6, D3ZND9
    Related
    ENSRNOP00000034041.6, ENSRNOT00000039377.6
    Conserved Domains (2) summary
    COG1718
    Location:214 → 461
    RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
    cd05146
    Location:253 → 453
    RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    3602535..3628108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277461.1 → XP_063133531.1  serine/threonine-protein kinase RIO3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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