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Sec61a2 SEC61 translocon subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361273, updated on 17-Aug-2024

Summary

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Official Symbol
Sec61a2provided by RGD
Official Full Name
SEC61 translocon subunit alpha 2provided by RGD
Primary source
RGD:1305948
See related
EnsemblRapid:ENSRNOG00000023278 AllianceGenome:RGD:1305948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and posttranslational protein targeting to membrane, translocation. Predicted to be integral component of membrane. Predicted to be part of Sec61 translocon complex. Orthologous to human SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 164.0), Heart (RPKM 135.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sec61a2 in Genome Data Viewer
Location:
17q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77316901..77354978)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (72407574..72445630)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76358947..76385860)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene cytochrome c oxidase subunit VIb polypeptide 1-like Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene nudix hydrolase 5 Neighboring gene cell division cycle 123 Neighboring gene uncharacterized LOC102551026

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Hori O, et al. Mol Cell Biol, 2006 Jun. PMID 16705175, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein transport protein Sec61 subunit alpha
Names
Sec61 alpha 2 subunit
Sec61 translocon alpha 2 subunit
Sec61, alpha subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170343.1 → NP_001163814.1  protein transport protein Sec61 subunit alpha

    See identical proteins and their annotated locations for NP_001163814.1

    Status: VALIDATED

    Source sequence(s)
    BG381529, CB327956, CD373126, CK470805, CO567453
    UniProtKB/TrEMBL
    A0A8I6AA70, A0A8I6GFI1
    Related
    ENSRNOP00000097707.2, ENSRNOT00000119882.2
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 469
    PTZ00219; Sec61 alpha subunit; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    77316901..77354978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095932.2 → XP_038951860.1  protein transport protein Sec61 subunit alpha isoform X1

    UniProtKB/TrEMBL
    D3ZEH3
    Related
    ENSRNOP00000082887.2, ENSRNOT00000100731.2
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 417
    PTZ00219; Sec61 alpha subunit; Provisional

  2. XM_006254257.5 → XP_006254319.1  protein transport protein Sec61 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8I6GFI1
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 381
    PTZ00219; Sec61 alpha subunit; Provisional

  3. XM_063276637.1 → XP_063132707.1  protein transport protein Sec61 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A0U1RRQ7, A0A8I5ZUP9
    Related
    ENSRNOP00000081267.1, ENSRNOT00000092448.3

  4. XM_039095933.2 → XP_038951861.1  protein transport protein Sec61 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q9G3
    Conserved Domains (1) summary
    PTZ00219
    Location:4 → 399
    PTZ00219; Sec61 alpha subunit; Provisional

RNA

  1. XR_005495306.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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