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Sugct succinylCoA:glutarate-CoA transferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361253, updated on 17-Aug-2024

Summary

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Official Symbol
Sugctprovided by RGD
Official Full Name
succinylCoA:glutarate-CoA transferaseprovided by RGD
Primary source
RGD:1308114
See related
EnsemblRapid:ENSRNOG00000066247 AllianceGenome:RGD:1308114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308114
Summary
Predicted to enable succinate-hydroxymethylglutarate CoA-transferase activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia type 3. Orthologous to human SUGCT (succinyl-CoA:glutarate-CoA transferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 262.2), Liver (RPKM 90.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sugct in Genome Data Viewer
Location:
17q11-q12.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (52072012..52929852)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (47376392..48234362)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (49991314..51030950)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 13 Neighboring gene M-phase specific PLK1 interacting protein Neighboring gene macrophage migration inhibitory factor, pseudogene Neighboring gene uncharacterized LOC108348564

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. Marlaire S, et al. J Inherit Metab Dis, 2014 Jan. PMID 23893049
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables succinate-hydroxymethylglutarate CoA-transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-hydroxymethylglutarate CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables succinate-hydroxymethylglutarate CoA-transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
succinate--hydroxymethylglutarate CoA-transferase
Names
caiB/baiF CoA-transferase family protein C7orf10 homolog
NP_001014168.1
XP_038951826.1
XP_038951827.1
XP_038951828.1
XP_038951829.1
XP_038951830.1
XP_038951831.1
XP_038951832.1
XP_038951834.1
XP_038951835.1
XP_038951837.1
XP_063132687.1
XP_063132688.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014146.1 → NP_001014168.1  succinate--hydroxymethylglutarate CoA-transferase

    See identical proteins and their annotated locations for NP_001014168.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079348
    UniProtKB/Swiss-Prot
    F1LXJ6, Q68FU4
    Related
    ENSRNOP00000079174.2, ENSRNOT00000108763.2
    Conserved Domains (1) summary
    COG1804
    Location:34 → 430
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    52072012..52929852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095899.2 → XP_038951827.1  succinate--hydroxymethylglutarate CoA-transferase isoform X2

    Related
    ENSRNOP00000109393.1, ENSRNOT00000139022.1
    Conserved Domains (1) summary
    pfam02515
    Location:39 → 374
    CoA_transf_3; CoA-transferase family III

  2. XM_039095902.2 → XP_038951830.1  succinate--hydroxymethylglutarate CoA-transferase isoform X4

    Conserved Domains (1) summary
    pfam02515
    Location:39 → 358
    CoA_transf_3; CoA-transferase family III

  3. XM_039095898.2 → XP_038951826.1  succinate--hydroxymethylglutarate CoA-transferase isoform X1

    Related
    ENSRNOP00000102580.1, ENSRNOT00000146890.1
    Conserved Domains (1) summary
    COG1804
    Location:34 → 413
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  4. XM_039095903.2 → XP_038951831.1  succinate--hydroxymethylglutarate CoA-transferase isoform X5

    Conserved Domains (1) summary
    COG1804
    Location:34 → 344
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  5. XM_063276617.1 → XP_063132687.1  succinate--hydroxymethylglutarate CoA-transferase isoform X6

  6. XM_039095901.2 → XP_038951829.1  succinate--hydroxymethylglutarate CoA-transferase isoform X3

    Related
    ENSRNOP00000100791.1, ENSRNOT00000137064.1
    Conserved Domains (1) summary
    COG1804
    Location:1 → 395
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  7. XM_039095900.2 → XP_038951828.1  succinate--hydroxymethylglutarate CoA-transferase isoform X3

    Conserved Domains (1) summary
    COG1804
    Location:1 → 395
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  8. XM_063276618.1 → XP_063132688.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

  9. XM_039095904.1 → XP_038951832.1  succinate--hydroxymethylglutarate CoA-transferase isoform X7

    Conserved Domains (1) summary
    COG1804
    Location:30 → 303
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  10. XM_039095906.1 → XP_038951834.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

    Conserved Domains (1) summary
    COG1804
    Location:1 → 292
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  11. XM_039095907.2 → XP_038951835.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

    Conserved Domains (1) summary
    COG1804
    Location:1 → 292
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  12. XM_039095909.2 → XP_038951837.1  succinate--hydroxymethylglutarate CoA-transferase isoform X9

    Conserved Domains (1) summary
    COG1804
    Location:1 → 264
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FU4.1 GenPept UniProtKB/Swiss-Prot:Q68FU4

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