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Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361243, updated on 2-Nov-2024

Summary

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Official Symbol
Cdkal1provided by RGD
Official Full Name
CDK5 regulatory subunit associated protein 1-like 1provided by RGD
Primary source
RGD:1310246
See related
EnsemblRapid:ENSRNOG00000072186 AllianceGenome:RGD:1310246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N6-threonylcarbomyladenosine methylthiotransferase activity. Predicted to act upstream of or within maintenance of translational fidelity and tRNA methylthiolation. Predicted to be located in rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; diabetic retinopathy; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 59.3), Thymus (RPKM 51.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdkal1 in Genome Data Viewer
Location:
17p12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (34927221..35479827)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (34718701..35271276)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (36451031..37157882)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L37-like 3 Neighboring gene uncharacterized LOC120097733 Neighboring gene uncharacterized LOC120097731 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. Brambillasca S, et al. J Biol Chem, 2012 Dec 7. PMID 23048041, Free PMC Article
  2. Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. Arragain S, et al. J Biol Chem, 2010 Sep 10. PMID 20584901, Free PMC Article
  3. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Peng D, et al. Sci Rep, 2017 Aug 18. PMID 28821857, Free PMC Article
  4. Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. Ohara-Imaizumi M, et al. PLoS One, 2010 Dec 9. PMID 21151568, Free PMC Article
  5. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. Wei FY, et al. J Clin Invest, 2011 Sep. PMID 21841312, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells.
    Title: CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables N6-threonylcarbomyladenosine methylthiotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within maintenance of translational fidelity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA methylthiolation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
threonylcarbamoyladenosine tRNA methylthiotransferase
NP_001389100.1
NP_001389101.1
XP_063132663.1
XP_063132664.1
XP_063132666.1
XP_063132667.1
XP_063132668.1
XP_063132669.1
XP_063132670.1
XP_063132671.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402171.2 → NP_001389100.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J7N5, F1LV76

  2. NM_001402172.2 → NP_001389101.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I5ZT83
    Related
    ENSRNOP00000081920.1, ENSRNOT00000116835.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    34927221..35479827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276598.1 → XP_063132668.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X3

  2. XM_063276594.1 → XP_063132664.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1

    UniProtKB/TrEMBL
    A6J7N5, F1LV76

  3. XM_063276597.1 → XP_063132667.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2

  4. XM_063276599.1 → XP_063132669.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X4

  5. XM_063276593.1 → XP_063132663.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1

    UniProtKB/TrEMBL
    A6J7N5, F1LV76

  6. XM_063276600.1 → XP_063132670.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X4

  7. XM_063276596.1 → XP_063132666.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1

    UniProtKB/TrEMBL
    A6J7N5, F1LV76

  8. XM_063276601.1 → XP_063132671.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108413.1: Suppressed sequence

    Description
    NM_001108413.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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