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psq pipsqueak [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36118, updated on 2-Nov-2024

Summary

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Official Symbol
psqprovided by FlyBase
Official Full Name
pipsqueakprovided by FlyBase
Primary source
FLYBASE:FBgn0263102
Locus tag
Dmel_CG2368
See related
AllianceGenome:FB:FBgn0263102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BTB-V; BtbV; CG2368; Dmel\CG2368; eyeful; Lola; pip; Pipsqueak; Piq; psk; Psq; PSQ; psq-1; rum; zep
Summary
Enables POZ domain binding activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in embryonic pattern specification; heterochromatin formation; and imaginal disc-derived wing morphogenesis. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including amnioserosa; gnathal segment; imaginal disc; outer photoreceptor cell; and photoreceptor precursor cell. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See psq in Genome Data Viewer
Location:
47A13-47B1; 2-62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10557888..10617280)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6445393..6504785)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene longitudinals lacking Neighboring gene antisense RNA:CR45135 Neighboring gene long non-coding RNA:acal Neighboring gene uncharacterized protein Neighboring gene G protein-coupled receptor kinase interacting ArfGAP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Small RNA analysis provides new insights into cytoplasmic incompatibility in Drosophila melanogaster induced by Wolbachia. Zheng Y, et al. J Insect Physiol, 2019 Oct. PMID 31491378
  2. Aberrant splicing and transcription termination caused by P element insertion into the intron of a Drosophila gene. Horowitz H, et al. Genetics, 1995 Jan. PMID 7705633, Free PMC Article
  3. High-resolution mapping of transcription factor binding sites on native chromatin. Kasinathan S, et al. Nat Methods, 2014 Feb. PMID 24336359, Free PMC Article
  4. Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12271134, Free PMC Article
  5. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis. Horowitz H, et al. Development, 1996 Jun. PMID 8674425

See all (178) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.
    Title: Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.
  2. whereas the bab locus controls the sorting of TFCs into TFs, psq plays a major function in global control of TFC number, without affecting sorting of TFCs into TFs.
    Title: Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors.
  3. characterized a new psq loss-of-function allele, psq(rum), which specifically affects signaling by the Torso (Tor) receptor tyrosine kinase (RTK)
    Title: Control of germline torso expression by the BTB/POZ domain protein pipsqueak is required for embryonic terminal patterning in Drosophila.
  4. Pipsqueak and GAGA factor are co-localized on polytene interphase chromosomes of Drosophila
    Title: Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci.
  5. The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins, which includes proteins from fungi, sea urchins, nematodes, insects, and vertebrates
    Title: The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins.
  6. Pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex.
    Title: pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex.
  7. the eyeful P-element insertion, which induces overexpression of lola and psq, combined with Delta overexpression induces metastatic tumors
    Title: Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables POZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo HMP PubMed 
involved_in embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pipsqueak
Names
BTB-protein-V
CG2368-PA
CG2368-PB
CG2368-PC
CG2368-PD
CG2368-PE
CG2368-PF
CG2368-PG
CG2368-PH
CG2368-PJ
CG2368-PK
CG2368-PM
CG2368-PN
CG2368-PO
CG2368-PP
CG2368-PQ
eyeful
peepsqueak
pipsqeak
psq-PA
psq-PB
psq-PC
psq-PD
psq-PE
psq-PF
psq-PG
psq-PH
psq-PJ
psq-PK
psq-PM
psq-PN
psq-PO
psq-PP
psq-PQ
rumpf
zeppelin
zepplin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10557888..10617280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382049.1 → NP_001369078.1  pipsqueak, isoform O [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7H0, Q24184, Q24187, Q9V5N1, Q9V5N2
    Conserved Domains (2) summary
    pfam05225
    Location:873 → 916
    HTH_psq; helix-turn-helix, Psq domain
    cd18315
    Location:34 → 118
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

  2. NM_001014520.3 → NP_001014520.2  pipsqueak, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014520.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8A6, Q24184, Q24187, Q9V5N1, Q9V5N2
    Conserved Domains (3) summary
    smart00225
    Location:36 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:25 → 125
    BTB; BTB/POZ domain
    pfam05225
    Location:873 → 916
    HTH_psq; helix-turn-helix, Psq domain

  3. NM_001316414.1 → NP_001303343.1  pipsqueak, isoform N [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUM1, Q24184, Q24187, Q9V5N1, Q9V5N2
    Conserved Domains (3) summary
    smart00225
    Location:36 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:25 → 125
    BTB; BTB/POZ domain
    pfam05225
    Location:873 → 916
    HTH_psq; helix-turn-helix, Psq domain

  4. NM_078962.4 → NP_523686.2  pipsqueak, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523686.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24184, Q24187, Q7K0T7, Q9V5N1, Q9V5N2
    Related
    FBpp0087368
    Conserved Domains (3) summary
    smart00225
    Location:36 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:25 → 125
    BTB; BTB/POZ domain
    pfam05225
    Location:889 → 932
    HTH_psq; helix-turn-helix, Psq domain

  5. NM_165790.3 → NP_724955.1  pipsqueak, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724955.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8A4, Q24184, Q24187, Q9V5N1, Q9V5N2
    Related
    FBpp0087369
    Conserved Domains (3) summary
    smart00225
    Location:36 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:25 → 125
    BTB; BTB/POZ domain
    pfam05225
    Location:871 → 914
    HTH_psq; helix-turn-helix, Psq domain

  6. NM_206086.3 → NP_995808.1  pipsqueak, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24184, Q24187, Q7K0T7, Q9V5N1, Q9V5N2
    Conserved Domains (3) summary
    smart00225
    Location:36 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:25 → 125
    BTB; BTB/POZ domain
    pfam05225
    Location:889 → 932
    HTH_psq; helix-turn-helix, Psq domain

  7. NM_165792.3 → NP_724959.1  pipsqueak, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724959.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9C8, Q7JP00
    Related
    FBpp0087370
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain

  8. NM_176141.3 → NP_788321.1  pipsqueak, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9C8, Q7JP00
    Related
    FBpp0087372
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain

  9. NM_176142.3 → NP_788322.1  pipsqueak, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788322.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9C8, Q7JP00
    Related
    FBpp0087373
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain

  10. NM_001014518.3 → NP_001014518.1  pipsqueak, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZC9, Q7JP00
    Conserved Domains (1) summary
    pfam05225
    Location:464 → 507
    HTH_psq; helix-turn-helix, Psq domain

  11. NM_001014519.3 → NP_001014519.1  pipsqueak, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZC9, Q7JP00
    Conserved Domains (1) summary
    pfam05225
    Location:464 → 507
    HTH_psq; helix-turn-helix, Psq domain

  12. NM_001382050.1 → NP_001369079.1  pipsqueak, isoform P [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3QAD4, Q7JP00
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain

  13. NM_001382051.1 → NP_001369080.1  pipsqueak, isoform Q [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7A2
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain

  14. NM_165791.3 → NP_724958.1  pipsqueak, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9C8, Q7JP00
    Related
    FBpp0087371
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain

  15. NM_176143.3 → NP_788323.1  pipsqueak, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9C8, Q7JP00
    Related
    FBpp0087374
    Conserved Domains (1) summary
    pfam05225
    Location:470 → 513
    HTH_psq; helix-turn-helix, Psq domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A126GUM1 A0A126GUM1
A0A6M3Q7A2 A0A6M3Q7A2
A0A6M3Q7H0 A0A6M3Q7H0
A0A6M3QAD4 A0A6M3QAD4
A1Z8A4 A1Z8A4
A1Z8A6 A1Z8A6
A4UZC9 A4UZC9
Q0E9C8 Q0E9C8
Q24455 Q24455
Q24457 Q24457
Q7JN04 Q7JN04
Q7JP00 Q7JP00
Q7JPL8 Q7JPL8
Q7K0T7 Q7K0T7
Q9V5N1 Q9V5N1

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