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Hgsnat heparan-alpha-glucosaminide N-acetyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361165, updated on 10-Oct-2024

Summary

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Symbol
Hgsnatprovided by RGD
Full Name
heparan-alpha-glucosaminide N-acetyltransferaseprovided by RGD
Primary source
RGD:1560755
See related
EnsemblRapid:ENSRNOG00000069796 AllianceGenome:RGD:1560755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560755
Summary
Predicted to enable acyltransferase activity. Predicted to be involved in lysosomal transport and protein complex oligomerization. Predicted to be located in lysosomal membrane. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type IIIC and retinitis pigmentosa 73. Orthologous to human HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 116.2), Lung (RPKM 109.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hgsnat in Genome Data Viewer
Location:
16q12.4
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72807967..72840180)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66105233..66137444)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (70876557..70909443)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene farnesyltransferase, CAAX box, subunit alpha Neighboring gene protein-O-mannose kinase Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 5 Neighboring gene potassium calcium-activated channel subfamily U member 1 Neighboring gene uncharacterized LOC120097390 Neighboring gene ASH2 like histone lysine methyltransferase complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein misfolding as an underlying molecular defect in mucopolysaccharidosis III type C. Feldhammer M, et al. PLoS One, 2009 Oct 13. PMID 19823584, Free PMC Article
  2. Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC. Durand S, et al. J Biol Chem, 2010 Oct 8. PMID 20650889, Free PMC Article
  3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108996

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables heparan-alpha-glucosaminide N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heparan-alpha-glucosaminide N-acetyltransferase
Names
RGD1560755 protein-like
NP_001389399.1
XP_056840862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402470.1 → NP_001389399.1  heparan-alpha-glucosaminide N-acetyltransferase precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IVZ9
    Related
    ENSRNOP00000080474.2, ENSRNOT00000097105.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    72807967..72840180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_056984882.2 → XP_056840862.1  heparan-alpha-glucosaminide N-acetyltransferase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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