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Zmiz1 zinc finger, MIZ-type containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361103, updated on 10-Jul-2024

Summary

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Symbol
Zmiz1provided by RGD
Full Name
zinc finger, MIZ-type containing 1provided by RGD
Primary source
RGD:1311620
See related
EnsemblRapid:ENSRNOG00000010488 AllianceGenome:RGD:1311620
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rai17
Summary
Predicted to enable SMAD binding activity and nuclear receptor coactivator activity. Predicted to be involved in several processes, including epigenetic maintenance of chromatin in transcription-competent conformation; regulation of nucleic acid-templated transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including circulatory system development; positive regulation of fibroblast proliferation; and vitellogenesis. Predicted to be located in cytosol and nucleoplasm. Orthologous to human ZMIZ1 (zinc finger MIZ-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 75.6), Lung (RPKM 41.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zmiz1 in Genome Data Viewer
Location:
16p16
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1033983..1239425)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1027083..1232616)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (1749191..1954633)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482436 Neighboring gene uncharacterized LOC120097507 Neighboring gene microRNA 3075 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene peptidylprolyl isomerase F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZMIZ1 Variants Cause a Syndromic Neurodevelopmental Disorder. Carapito R, et al. Am J Hum Genet, 2019 Feb 7. PMID 30639322, Free PMC Article
  2. hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. Sharma M, et al. EMBO J, 2003 Nov 17. PMID 14609956, Free PMC Article
  3. The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Beliakoff J, et al. Mol Cell Biol, 2008 Jan. PMID 17967885, Free PMC Article
  4. Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Tarunina M, et al. Mol Cell Biol, 2004 Dec. PMID 15572682, Free PMC Article
  5. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. Li X, et al. J Biol Chem, 2006 Aug 18. PMID 16777850

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within artery morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within developmental growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyramidal neuron migration to cerebral cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vitellogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger MIZ domain-containing protein 1
Names
retinoic acid induced 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108393.1 → NP_001101863.1  zinc finger MIZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_001101863.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474067
    UniProtKB/TrEMBL
    A6KMH0, D4AE97
    Related
    ENSRNOP00000014003.5, ENSRNOT00000014004.9
    Conserved Domains (3) summary
    PHA03247
    Location:183 → 562
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:746 → 793
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8 → 100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    1033983..1239425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275487.1 → XP_063131557.1  zinc finger MIZ domain-containing protein 1 isoform X4

    Related
    ENSRNOP00000082013.2, ENSRNOT00000101223.2

  2. XM_063275482.1 → XP_063131552.1  zinc finger MIZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KMH0, D4AE97

  3. XM_063275484.1 → XP_063131554.1  zinc finger MIZ domain-containing protein 1 isoform X2

  4. XM_006252539.5 → XP_006252601.1  zinc finger MIZ domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZU59
    Conserved Domains (2) summary
    pfam02891
    Location:745 → 793
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam04487
    Location:325 → 450
    CITED; CITED

  5. XM_006252538.5 → XP_006252600.1  zinc finger MIZ domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02891
    Location:739 → 787
    zf-MIZ; MIZ/SP-RING zinc finger

  6. XM_063275483.1 → XP_063131553.1  zinc finger MIZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KMH0, D4AE97

  7. XM_063275481.1 → XP_063131551.1  zinc finger MIZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KMH0, D4AE97

  8. XM_063275485.1 → XP_063131555.1  zinc finger MIZ domain-containing protein 1 isoform X2

  9. XM_063275488.1 → XP_063131558.1  zinc finger MIZ domain-containing protein 1 isoform X4

  10. XM_039094612.2 → XP_038950540.1  zinc finger MIZ domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:59 → 438
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:622 → 669
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  11. XM_039094611.2 → XP_038950539.1  zinc finger MIZ domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:59 → 438
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:622 → 669
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  12. XM_017600163.3 → XP_017455652.1  zinc finger MIZ domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:59 → 438
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:622 → 669
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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