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Dmtn dematin actin binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 361069, updated on 14-Nov-2024

Summary

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Official Symbol
Dmtnprovided by RGD
Official Full Name
dematin actin binding proteinprovided by RGD
Primary source
RGD:1311419
See related
EnsemblRapid:ENSRNOG00000012273 AllianceGenome:RGD:1311419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Epb49; Epb4.9
Summary
Predicted to enable actin filament binding activity; signaling receptor binding activity; and spectrin binding activity. Predicted to be involved in several processes, including negative regulation of cell-substrate adhesion; negative regulation of protein phosphorylation; and regulation of plasma membrane bounded cell projection assembly. Predicted to be located in several cellular components, including cytoskeleton; platelet dense tubular network membrane; and postsynaptic density. Predicted to be active in actin cytoskeleton; plasma membrane; and synapse. Orthologous to human DMTN (dematin actin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 220.0), Brain (RPKM 165.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmtn in Genome Data Viewer
Location:
15p11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52087667..52111956, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45677974..45702261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52292762..52320385, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 18 Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene fibroblast growth factor 17 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene uncharacterized LOC134482146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). Chen L, et al. J Biol Chem, 2013 Mar 22. PMID 23355471, Free PMC Article
  2. Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction. Koshino I, et al. J Biol Chem, 2012 Oct 12. PMID 22927433, Free PMC Article
  3. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Chen L, et al. Protein Sci, 2009 Mar. PMID 19241372, Free PMC Article
  4. Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression. Lutchman M, et al. Cancer Genet Cytogenet, 1999 Nov. PMID 10565303
  5. The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation. Mohseni M, et al. Mol Cell Biol, 2008 Aug. PMID 18505823, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum tubular network organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in platelet dense tubular network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in spectrin-associated cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dematin
Names
erythrocyte membrane protein band 4.9 (dematin)
erythrocyte protein band 4.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394746.1 → NP_001381675.1  dematin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    Related
    ENSRNOP00000097697.2, ENSRNOT00000106565.2
    Conserved Domains (2) summary
    smart00153
    Location:370 → 405
    VHP; Villin headpiece domain
    pfam16182
    Location:8 → 369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. NM_001394747.1 → NP_001381676.1  dematin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6HTM3, D4A559
    Related
    ENSRNOP00000059386.2, ENSRNOT00000067776.5
    Conserved Domains (2) summary
    smart00153
    Location:348 → 383
    VHP; Villin headpiece domain
    pfam16182
    Location:8 → 347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. NM_001394748.1 → NP_001381677.1  dematin isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I5ZXT2
    Related
    ENSRNOP00000084709.1, ENSRNOT00000097002.2
    Conserved Domains (2) summary
    smart00153
    Location:345 → 380
    VHP; Villin headpiece domain
    pfam16182
    Location:7 → 344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    52087667..52111956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108385.1: Suppressed sequence

    Description
    NM_001108385.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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