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Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361063, updated on 2-Nov-2024

Summary

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Official Symbol
Entpd4provided by RGD
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 4provided by RGD
Primary source
RGD:1309511
See related
EnsemblRapid:ENSRNOG00000016321 AllianceGenome:RGD:1309511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleobase-containing small molecule catabolic process and ribonucleotide metabolic process. Predicted to be located in Golgi membrane and autophagosome membrane. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 264.8), Adrenal (RPKM 230.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Entpd4 in Genome Data Viewer
Location:
15p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51040665..51068450)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (44630878..44658654)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51222954..51250787)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene syncytin b Neighboring gene Set nuclear proto-oncogene, pseudogene 13 Neighboring gene lysyl oxidase-like 2 Neighboring gene R3H domain and coiled-coil containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. Biederbick A, et al. J Cell Sci, 1999 Aug. PMID 10393803
  2. Golgi localization and functional expression of human uridine diphosphatase. Wang TF, et al. J Biol Chem, 1998 May 1. PMID 9556635
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CTP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing small molecule catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 4
NP_001388593.1
NP_001388594.1
XP_006252338.1
XP_063130500.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401664.1 → NP_001388593.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6HTH4
    Related
    ENSRNOP00000070148.3, ENSRNOT00000088928.3

  2. NM_001401665.1 → NP_001388594.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2JX61
    Related
    ENSRNOP00000063756.2, ENSRNOT00000064428.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    51040665..51068450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274430.1 → XP_063130500.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX61

  2. XM_006252276.5 → XP_006252338.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1

    See identical proteins and their annotated locations for XP_006252338.1

    UniProtKB/TrEMBL
    A6HTH4
    Related
    ENSRNOP00000104975.1, ENSRNOT00000143533.1
    Conserved Domains (1) summary
    cl17037
    Location:82 → 540
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108384.1: Suppressed sequence

    Description
    NM_001108384.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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