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Ebf2 EBF transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361060, updated on 2-Nov-2024

Summary

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Official Symbol
Ebf2provided by RGD
Official Full Name
EBF transcription factor 2provided by RGD
Primary source
RGD:1310805
See related
EnsemblRapid:ENSRNOG00000011548 AllianceGenome:RGD:1310805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 55.5), Adrenal (RPKM 47.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ebf2 in Genome Data Viewer
Location:
15p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (45610949..45809828)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (41435509..41634403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (43905099..44103742)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555410 Neighboring gene uncharacterized LOC134482137 Neighboring gene large ribosomal subunit protein eL6-like Neighboring gene uncharacterized LOC134482138 Neighboring gene uncharacterized LOC120097021 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Stine RR, et al. Mol Metab, 2016 Jan. PMID 26844207, Free PMC Article
  2. Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain. Malgaretti N, et al. J Biol Chem, 1997 Jul 11. PMID 9211912
  3. Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection. Wang SS, et al. Mol Cell Neurosci, 2002 Jul. PMID 12139918
  4. EBF2 determines and maintains brown adipocyte identity. Rajakumari S, et al. Cell Metab, 2013 Apr 2. PMID 23499423, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell fate determination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor COE2
Names
early B-cell factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108383.1 → NP_001101853.1  transcription factor COE2

    See identical proteins and their annotated locations for NP_001101853.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474023
    UniProtKB/TrEMBL
    A6K6P4, D3ZT68
    Related
    ENSRNOP00000016568.4, ENSRNOT00000016568.6
    Conserved Domains (3) summary
    cd01175
    Location:253 → 337
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:20 → 246
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:338 → 381
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. NM_001431585.1 → NP_001418514.1  transcription factor COE2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K6P4, D3ZT68

  3. NM_001431586.1 → NP_001418515.1  transcription factor COE2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K6P4, D3ZT68

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    45610949..45809828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252133.5 → XP_006252195.1  transcription factor COE2 isoform X1

    Conserved Domains (3) summary
    cd01175
    Location:253 → 337
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:20 → 246
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:338 → 381
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
Nucleotide Protein Strain
Heading Accession and Version

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