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Helq helicase, POLQ-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 360912, updated on 2-Nov-2024

Summary

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Official Symbol
Helqprovided by RGD
Official Full Name
helicase, POLQ-likeprovided by RGD
Primary source
RGD:1560216
See related
EnsemblRapid:ENSRNOG00000002181 AllianceGenome:RGD:1560216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hel308
Summary
Predicted to enable single-stranded 3'-5' DNA helicase activity. Predicted to be involved in double-strand break repair and positive regulation of double-strand break repair via homologous recombination. Predicted to be active in nucleus and site of DNA damage. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 48.2), Spleen (RPKM 41.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Helq in Genome Data Viewer
Location:
14p22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9122978..9167310)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (8818582..8862926)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10446981..10491042)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene uncharacterized LOC134481712 Neighboring gene uncharacterized LOC108352710 Neighboring gene heparanase Neighboring gene peptidylprolyl isomerase D, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DNA polymerase POLN participates in cross-link repair and homologous recombination. Moldovan GL, et al. Mol Cell Biol, 2010 Feb. PMID 19995904, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA double-strand break processing involved in repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via alternative nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
helicase POLQ-like
Names
DNA helicase HEL308
NP_001014156.2
XP_008768262.1
XP_008768263.1
XP_038948085.1
XP_063129394.1
XP_063129396.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014134.2 → NP_001014156.2  helicase POLQ-like

    See identical proteins and their annotated locations for NP_001014156.2

    Status: VALIDATED

    Source sequence(s)
    CH474022
    UniProtKB/TrEMBL
    A6K5Y2, E9PT19
    Related
    ENSRNOP00000002974.5, ENSRNOT00000002974.8
    Conserved Domains (4) summary
    smart00490
    Location:589 → 667
    HELICc; helicase superfamily c-terminal domain
    PRK02362
    Location:273 → 1020
    PRK02362; ski2-like helicase; Provisional
    pfam00270
    Location:300 → 461
    DEAD; DEAD/DEAH box helicase
    pfam14520
    Location:967 → 1020
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    9122978..9167310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273324.1 → XP_063129394.1  helicase POLQ-like isoform X1

    Related
    ENSRNOP00000083721.2, ENSRNOT00000113418.2

  2. XM_039092157.2 → XP_038948085.1  helicase POLQ-like isoform X2

    Related
    ENSRNOP00000104289.1, ENSRNOT00000122711.1
    Conserved Domains (2) summary
    PRK02362
    Location:273 → 962
    PRK02362; ATP-dependent DNA helicase
    cd18026
    Location:274 → 476
    DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta

  3. XM_063273326.1 → XP_063129396.1  helicase POLQ-like isoform X4

  4. XM_008770040.3 → XP_008768262.1  helicase POLQ-like isoform X3

    See identical proteins and their annotated locations for XP_008768262.1

    UniProtKB/TrEMBL
    A6K5Y5
    Conserved Domains (4) summary
    smart00490
    Location:238 → 316
    HELICc; helicase superfamily c-terminal domain
    PRK02362
    Location:39 → 669
    PRK02362; ski2-like helicase; Provisional
    pfam14520
    Location:616 → 669
    HHH_5; Helix-hairpin-helix domain
    cl21455
    Location:1 → 110
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_008770041.3 → XP_008768263.1  helicase POLQ-like isoform X5

    Conserved Domains (3) summary
    smart00490
    Location:90 → 168
    HELICc; helicase superfamily c-terminal domain
    PRK02362
    Location:15 → 521
    PRK02362; ski2-like helicase; Provisional
    pfam14520
    Location:468 → 521
    HHH_5; Helix-hairpin-helix domain
Nucleotide Protein Strain
Heading Accession and Version

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