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Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 360893, updated on 2-Nov-2024

Summary

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Official Symbol
Taf1aprovided by RGD
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I subunit Aprovided by RGD
Primary source
RGD:1305698
See related
EnsemblRapid:ENSRNOG00000061139 AllianceGenome:RGD:1305698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be part of RNA polymerase transcription factor SL1 complex. Orthologous to human TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 44.7), Thymus (RPKM 42.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Taf1a in Genome Data Viewer
Location:
13q26
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97543772..97579742)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (95012160..95048131)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101770278..101807975)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096335 Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC108352586 Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 4 Neighboring gene uncharacterized LOC120096336 Neighboring gene HHIP like 2 Neighboring gene uncharacterized LOC102555798

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article
  2. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA. Gene, 2012 Feb 10. PMID 21893173, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC125031

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase transcription factor SL1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase transcription factor SL1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit A
Names
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
TATA box-binding protein-associated factor 1A
TBP-associated factor 1A
transcription initiation factor SL1/TIF-IB subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037204.1 → NP_001032281.1  TATA box-binding protein-associated factor RNA polymerase I subunit A

    See identical proteins and their annotated locations for NP_001032281.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107466
    UniProtKB/Swiss-Prot
    Q3B7U2
    UniProtKB/TrEMBL
    A6JGN7
    Conserved Domains (1) summary
    pfam14929
    Location:64 → 424
    TAF1_subA; TAF RNA Polymerase I subunit A

  2. NM_001429816.1 → NP_001416745.1  TATA box-binding protein-associated factor RNA polymerase I subunit A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q3B7U2

  3. NM_001429817.1 → NP_001416746.1  TATA box-binding protein-associated factor RNA polymerase I subunit A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q3B7U2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    97543772..97579742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090934.2 → XP_038946862.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X1

    UniProtKB/TrEMBL
    A6JGN7
    Conserved Domains (1) summary
    pfam14929
    Location:75 → 435
    TAF1_subA; TAF RNA Polymerase I subunit A

  2. XM_039090935.1 → XP_038946863.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

    Related
    ENSRNOP00000068899.2, ENSRNOT00000087784.3
    Conserved Domains (1) summary
    pfam14929
    Location:64 → 424
    TAF1_subA; TAF RNA Polymerase I subunit A

  3. XM_039090936.2 → XP_038946864.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

    Conserved Domains (1) summary
    pfam14929
    Location:64 → 424
    TAF1_subA; TAF RNA Polymerase I subunit A

  4. XM_039090937.2 → XP_038946865.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X3

    UniProtKB/TrEMBL
    A6JGN7
    Conserved Domains (1) summary
    pfam14929
    Location:1 → 347
    TAF1_subA; TAF RNA Polymerase I subunit A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7U2.1 GenPept UniProtKB/Swiss-Prot:Q3B7U2

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