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Hscb HscB mitochondrial iron-sulfur cluster co-chaperone [ Rattus norvegicus (Norway rat) ]

Gene ID: 360826, updated on 2-Nov-2024

Summary

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Official Symbol
Hscbprovided by RGD
Official Full Name
HscB mitochondrial iron-sulfur cluster co-chaperoneprovided by RGD
Primary source
RGD:1311005
See related
EnsemblRapid:ENSRNOG00000037508 AllianceGenome:RGD:1311005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311005
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in [2Fe-2S] cluster assembly and primitive erythrocyte differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 134.6), Spleen (RPKM 128.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hscb in Genome Data Viewer
Location:
12q16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51481318..51491689)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45821527..45831902)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51878267..51888645)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC120096015 Neighboring gene checkpoint kinase 2 Neighboring gene uncharacterized LOC120096017 Neighboring gene unc-51 like autophagy activating kinase 1 Neighboring gene pseudouridine synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. Uhrigshardt H, et al. Hum Mol Genet, 2010 Oct 1. PMID 20668094, Free PMC Article
  2. Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery. Maio N, et al. Cell Metab, 2014 Mar 4. PMID 24606901, Free PMC Article
  3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in primitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
iron-sulfur cluster co-chaperone protein HscB
Names
HscB iron-sulfur cluster co-chaperone homolog
iron-sulfur cluster co-chaperone protein HscB, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108340.1 → NP_001101810.1  iron-sulfur cluster co-chaperone protein HscB precursor

    See identical proteins and their annotated locations for NP_001101810.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J288, D3ZME7
    Related
    ENSRNOP00000053641.2, ENSRNOT00000056798.5
    Conserved Domains (2) summary
    PRK03578
    Location:67 → 227
    hscB; Fe-S protein assembly co-chaperone HscB
    pfam18256
    Location:38 → 64
    HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    51481318..51491689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769340.3 → XP_008767562.1  iron-sulfur cluster co-chaperone protein HscB isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2K9
    Related
    ENSRNOP00000085570.2, ENSRNOT00000102335.2
    Conserved Domains (3) summary
    PRK03578
    Location:67 → 189
    hscB; co-chaperone HscB; Provisional
    pfam07743
    Location:157 → 189
    HSCB_C; HSCB C-terminal oligomerization domain
    pfam16919
    Location:40 → 60
    PknG_rubred; Protein kinase G rubredoxin domain

  2. XM_006249564.4 → XP_006249626.1  iron-sulfur cluster co-chaperone protein HscB isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYF5
    Related
    ENSRNOP00000101643.1, ENSRNOT00000162294.1
    Conserved Domains (3) summary
    PRK03578
    Location:67 → 211
    hscB; co-chaperone HscB; Provisional
    pfam07743
    Location:157 → 212
    HSCB_C; HSCB C-terminal oligomerization domain
    pfam16919
    Location:40 → 60
    PknG_rubred; Protein kinase G rubredoxin domain

  3. XM_039089617.2 → XP_038945545.1  iron-sulfur cluster co-chaperone protein HscB isoform X4

    UniProtKB/TrEMBL
    A6J289
    Conserved Domains (2) summary
    PRK03578
    Location:67 → 141
    hscB; Fe-S protein assembly co-chaperone HscB
    pfam18256
    Location:38 → 64
    HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

  4. XM_039089618.2 → XP_038945546.1  iron-sulfur cluster co-chaperone protein HscB isoform X6

    Conserved Domains (2) summary
    PRK03578
    Location:67 → 142
    hscB; Fe-S protein assembly co-chaperone HscB
    pfam18256
    Location:38 → 64
    HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

  5. XM_039089616.2 → XP_038945544.1  iron-sulfur cluster co-chaperone protein HscB isoform X3

    Conserved Domains (2) summary
    PRK03578
    Location:67 → 142
    hscB; Fe-S protein assembly co-chaperone HscB
    pfam18256
    Location:38 → 64
    HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

  6. XM_063271547.1 → XP_063127617.1  iron-sulfur cluster co-chaperone protein HscB isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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