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Lztr1 leucine zipper like post translational regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360745, updated on 2-Nov-2024

Summary

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Official Symbol
Lztr1provided by RGD
Official Full Name
leucine zipper like post translational regulator 1provided by RGD
Primary source
RGD:1309100
See related
EnsemblRapid:ENSRNOG00000001870 AllianceGenome:RGD:1309100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and protein ubiquitination. Predicted to be located in recycling endosome membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; neurilemmoma; and schwannomatosis (multiple). Orthologous to human LZTR1 (leucine zipper like post translational regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 134.2), Brain (RPKM 131.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lztr1 in Genome Data Viewer
Location:
11q23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96991956..97008127, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83487717..83503896, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87381638..87397849)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene THAP domain containing 7 Neighboring gene apoptosis inducing factor, mitochondria associated 3 Neighboring gene CRK like proto-oncogene, adaptor protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The integrated landscape of driver genomic alterations in glioblastoma. Frattini V, et al. Nat Genet, 2013 Oct. PMID 23917401, Free PMC Article
  2. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, et al. Cell, 2017 Jun 15. PMID 28622513, Free PMC Article
  3. LZTR1-Related Hypertrophic Cardiomyopathy Without Typical Noonan Syndrome Features. Jenkins J, et al. Circ Genom Precis Med, 2020 Apr. PMID 32004086
  4. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis. Nacak TG, et al. J Biol Chem, 2006 Feb 24. PMID 16356934
  5. Providing more evidence on LZTR1 variants in Noonan syndrome patients. Chinton J, et al. Am J Med Genet A, 2020 Feb. PMID 31825158

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-zipper-like transcriptional regulator 1
Names
leucine-zipper-like transcription regulator 1
leucine-zipper-like transcriptional regulator, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108326.2 → NP_001101796.1  leucine-zipper-like transcriptional regulator 1

    See identical proteins and their annotated locations for NP_001101796.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169071
    UniProtKB/TrEMBL
    A0A8I5Y0T3, A6JSL5, B5DFI4, F7FP96
    Related
    ENSRNOP00000082766.2, ENSRNOT00000101549.2
    Conserved Domains (6) summary
    PLN02153
    Location:65 → 347
    PLN02153; epithiospecifier protein
    sd00038
    Location:65 → 111
    Kelch; KELCH repeat [structural motif]
    cd18308
    Location:417 → 568
    BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    cd18309
    Location:644 → 769
    BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    cd18505
    Location:572 → 630
    BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    cd18506
    Location:765 → 825
    BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96991956..97008127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248707.5 → XP_006248769.1  leucine-zipper-like transcriptional regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0T3
    Related
    ENSRNOP00000002554.6, ENSRNOT00000002554.8
    Conserved Domains (6) summary
    smart00225
    Location:665 → 762
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd14821
    Location:571 → 631
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    sd00038
    Location:65 → 111
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:662 → 761
    BTB; BTB/POZ domain
    pfam01344
    Location:280 → 323
    Kelch_1; Kelch motif
    pfam13415
    Location:74 → 123
    Kelch_3; Galactose oxidase, central domain

  2. XM_039088534.2 → XP_038944462.1  leucine-zipper-like transcriptional regulator 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y0T3
    Conserved Domains (7) summary
    PLN02153
    Location:31 → 278
    PLN02153; epithiospecifier protein
    sd00038
    Location:46 → 95
    Kelch; KELCH repeat [structural motif]
    cd18308
    Location:291 → 442
    BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    cd18309
    Location:518 → 643
    BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    cd18505
    Location:446 → 504
    BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    cd18506
    Location:639 → 674
    BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
    pfam13415
    Location:1 → 54
    Kelch_3; Galactose oxidase, central domain

  3. XM_063270661.1 → XP_063126731.1  leucine-zipper-like transcriptional regulator 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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