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Plekhh3 pleckstrin homology, MyTH4 and FERM domain containing H3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360634, updated on 2-Nov-2024

Summary

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Official Symbol
Plekhh3provided by RGD
Official Full Name
pleckstrin homology, MyTH4 and FERM domain containing H3provided by RGD
Primary source
RGD:1304854
See related
EnsemblRapid:ENSRNOG00000020238 AllianceGenome:RGD:1304854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304854
Summary
Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Orthologous to human PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 91.1), Heart (RPKM 63.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekhh3 in Genome Data Viewer
Location:
10q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86598749..86607482, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86098461..86106931, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89076467..89084952, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2 Neighboring gene contactin associated protein 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene uncharacterized LOC134480876

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC124855

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family H member 3
Names
PH domain-containing family H member 3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037202.1 → NP_001032279.1  pleckstrin homology domain-containing family H member 3 precursor

    See identical proteins and their annotated locations for NP_001032279.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107561
    UniProtKB/Swiss-Prot
    Q3B7L1
    UniProtKB/TrEMBL
    A0A8I6A8P7
    Related
    ENSRNOP00000087912.1, ENSRNOT00000110148.2
    Conserved Domains (6) summary
    cd13297
    Location:84 → 208
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    pfam00169
    Location:96 → 199
    PH; PH domain
    pfam00784
    Location:288 → 397
    MyTH4; MyTH4 domain
    cl00155
    Location:409 → 496
    UBQ; Ubiquitin-like proteins
    cl09511
    Location:511 → 550
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:658 → 745
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86598749..86607482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247365.5 → XP_006247427.1  pleckstrin homology domain-containing family H member 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8P7, A0A8L2QGA8
    Related
    ENSRNOP00000027452.6, ENSRNOT00000027452.8
    Conserved Domains (5) summary
    cd13297
    Location:84 → 208
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    pfam00784
    Location:288 → 397
    MyTH4; MyTH4 domain
    cl09511
    Location:514 → 553
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:661 → 748
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:401 → 500
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7L1.1 GenPept UniProtKB/Swiss-Prot:Q3B7L1

Gene LinkOut

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