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Mlx MAX dimerization protein MLX [ Rattus norvegicus (Norway rat) ]

Gene ID: 360631, updated on 2-Nov-2024

Summary

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Official Symbol
Mlxprovided by RGD
Official Full Name
MAX dimerization protein MLXprovided by RGD
Primary source
RGD:1308590
See related
EnsemblRapid:ENSRNOG00000019983 AllianceGenome:RGD:1308590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tcfl4
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 190.7), Kidney (RPKM 187.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mlx in Genome Data Viewer
Location:
10q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86519517..86524607)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86019216..86024326)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88997011..89002154)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene Coenzyme A synthase Neighboring gene PSMC3 interacting protein Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin, gamma 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis. Tamura N, et al. Circ Genom Precis Med, 2018 Oct. PMID 30354298, Free PMC Article
  2. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. Xu J, et al. J Biol Chem, 2006 Jul 7. PMID 16644726, Free PMC Article
  3. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Terao C, et al. Am J Hum Genet, 2013 Aug 8. PMID 23830516, Free PMC Article
  4. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. Ma L, et al. J Biol Chem, 2006 Sep 29. PMID 16885160
  5. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Billin AN, et al. Mol Cell Biol, 2000 Dec. PMID 11073985, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. involved in control of hepatic L-type pyruvate kinase gene transcription
    Title: Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
  2. ChREBP.Mlx is the principal transcription factor regulating glucose-responsive genes in the liver and coordinately regulates a family of genes required for glucose utilization and energy storage
    Title: ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
max-like protein X
Names
MLX, MAX dimerization protein
max-like factor protein
transcription factor-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034112.1 → NP_001029284.1  max-like protein X

    See identical proteins and their annotated locations for NP_001029284.1

    Status: VALIDATED

    Source sequence(s)
    BI286092, BQ194554, CO560831, CO574572
    UniProtKB/TrEMBL
    A2VCV8
    Conserved Domains (1) summary
    cd19687
    Location:129 → 205
    bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86519517..86524607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269439.1 → XP_063125509.1  max-like protein X isoform X3

  2. XM_063269440.1 → XP_063125510.1  max-like protein X isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZVP0
    Related
    ENSRNOP00000083006.1, ENSRNOT00000106512.2

  3. XM_006247362.5 → XP_006247424.1  max-like protein X isoform X4

    See identical proteins and their annotated locations for XP_006247424.1

    UniProtKB/TrEMBL
    A6HJ81, F7F8B8, Q2I1Y9, Q2I1Z0
    Related
    ENSRNOP00000027116.5, ENSRNOT00000027116.7
    Conserved Domains (1) summary
    cd19687
    Location:75 → 151
    bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins

  4. XM_039086405.2 → XP_038942333.1  max-like protein X isoform X6

    UniProtKB/TrEMBL
    A0A8I6GJW1, A6HJ82, F7F8B8
    Related
    ENSRNOP00000091763.1, ENSRNOT00000119770.2
    Conserved Domains (1) summary
    cd19687
    Location:45 → 121
    bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins

  5. XM_017597398.3 → XP_017452887.1  max-like protein X isoform X1

  6. XM_039086404.2 → XP_038942332.1  max-like protein X isoform X2

    UniProtKB/TrEMBL
    F7F8B8
    Conserved Domains (1) summary
    cd19687
    Location:99 → 175
    bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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