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P4ha2 prolyl 4-hydroxylase subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360526, updated on 2-Nov-2024

Summary

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Official Symbol
P4ha2provided by RGD
Official Full Name
prolyl 4-hydroxylase subunit alpha 2provided by RGD
Primary source
RGD:1309673
See related
EnsemblRapid:ENSRNOG00000033663 AllianceGenome:RGD:1309673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to act upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in myopia. Orthologous to human P4HA2 (prolyl 4-hydroxylase subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 99.7), Heart (RPKM 98.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See P4ha2 in Genome Data Viewer
Location:
10q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38743894..38772741)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38243136..38271983)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39435227..39464134)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 4 Neighboring gene PDZ and LIM domain 4 Neighboring gene casein kinase 2 alpha 1, pseudogene 1 Neighboring gene colony stimulating factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. Helaakoski T, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753822, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of procollagen-proline 4-dioxygenase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-2
Names
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
prolyl 4-hydroxylase, alpha polypeptide II
NP_001101745.1
NP_001386468.1
NP_001386469.1
NP_001386470.1
NP_001386471.1
NP_001386472.1
XP_008765913.1
XP_017452859.1
XP_038942230.1
XP_063125401.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108275.3 → NP_001101745.1  prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001101745.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ASK1, A6HEG7, A6HEG8
    Conserved Domains (2) summary
    smart00702
    Location:346 → 519
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 104
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  2. NM_001399539.1 → NP_001386468.1  prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ASK1, A6HEG7

  3. NM_001399540.1 → NP_001386469.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ACJ4

  4. NM_001399541.1 → NP_001386470.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ACJ4

  5. NM_001399542.1 → NP_001386471.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ACJ4

  6. NM_001399543.1 → NP_001386472.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ACJ4
    Related
    ENSRNOP00000089755.1, ENSRNOT00000104075.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    38743894..38772741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767691.4 → XP_008765913.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_008765913.1

    UniProtKB/TrEMBL
    A0A8I6ASK1, A6HEG7, A6HEG8
    Conserved Domains (2) summary
    smart00702
    Location:346 → 519
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 104
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  2. XM_039086302.2 → XP_038942230.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASK1, A6HEG7, A6HEG8
    Related
    ENSRNOP00000097385.1, ENSRNOT00000106136.2
    Conserved Domains (2) summary
    smart00702
    Location:346 → 519
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 104
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  3. XM_063269331.1 → XP_063125401.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACJ4

  4. XM_017597370.3 → XP_017452859.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASK1, A6HEG7, A6HEG8
    Conserved Domains (2) summary
    smart00702
    Location:346 → 519
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 104
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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