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Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360514, updated on 2-Nov-2024

Summary

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Official Symbol
Ublcp1provided by RGD
Official Full Name
ubiquitin-like domain containing CTD phosphatase 1provided by RGD
Primary source
RGD:1310386
See related
EnsemblRapid:ENSRNOG00000004477 AllianceGenome:RGD:1310386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310386
Summary
Predicted to enable proteasome regulatory particle binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of ATP-dependent activity and regulation of proteasome assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human UBLCP1 (ubiquitin like domain containing CTD phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 281.7), Thymus (RPKM 270.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ublcp1 in Genome Data Viewer
Location:
10q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (29447081..29462446, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28945690..28961103, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (30103607..30118945, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene interleukin 12B Neighboring gene GINS complex subunit 4, pseudogene 1 Neighboring gene ring finger protein 145 Neighboring gene uncharacterized LOC120095078

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105972

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome regulatory particle binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome regulatory particle binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ATP-dependent activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteasome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-like domain-containing CTD phosphatase 1
Names
nuclear proteasome inhibitor UBLCP1
NP_001014139.1
NP_001381239.1
XP_038942223.1
XP_063125396.1
XP_063125397.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014117.2 → NP_001014139.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_001014139.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5FWT7
    UniProtKB/TrEMBL
    A0A0H2UHC8, A6HDP3
    Related
    ENSRNOP00000006063.7, ENSRNOT00000006063.9
    Conserved Domains (2) summary
    TIGR02245
    Location:117 → 311
    HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
    cd01813
    Location:3 → 77
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

  2. NM_001394310.1 → NP_001381239.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0H2UHC8
    Conserved Domains (2) summary
    TIGR02245
    Location:107 → 301
    HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
    cd01813
    Location:3 → 77
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    29447081..29462446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269326.1 → XP_063125396.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X1

  2. XM_063269327.1 → XP_063125397.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X2

  3. XM_039086295.2 → XP_038942223.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X3

    Conserved Domains (2) summary
    cd01813
    Location:3 → 77
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins
    cl21460
    Location:117 → 149
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWT7.1 GenPept UniProtKB/Swiss-Prot:Q5FWT7

Gene LinkOut

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