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PRAC2 PRAC2 small nuclear protein [ Homo sapiens (human) ]

Gene ID: 360205, updated on 5-Mar-2024

Summary

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Official Symbol
PRAC2provided by HGNC
Official Full Name
PRAC2 small nuclear proteinprovided by HGNC
Primary source
HGNC:HGNC:30143
See related
Ensembl:ENSG00000229637 MIM:610787; AllianceGenome:HGNC:30143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOXBAS5; C17orf93; HOXB-AS5; HOXB13-AS1; NCRNA00253
Summary
This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in prostate (RPKM 2.7), colon (RPKM 1.1) and 1 other tissue See more
Orthologs
all
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Genomic context

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See PRAC2 in Genome Data Viewer
Location:
17q21.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48718666..48724758)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49582267..49588359)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46800547..46802120)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2086 Neighboring gene ribosomal protein L9 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:46790297-46790470 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46799826-46800340 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46800341-46800856 Neighboring gene PRAC1 small nuclear protein Neighboring gene microRNA 3185 Neighboring gene homeobox B13 Neighboring gene uncharacterized LOC105371811

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inflammation-associated DNA methylation patterns in epithelium of ulcerative colitis. Barnicle A, et al. Epigenetics, 2017 Aug. PMID 28557546, Free PMC Article
  2. PRAC2: a new gene expressed in human prostate and prostate cancer. Olsson P, et al. Prostate, 2003 Jul 1. PMID 12746837
  3. Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma. Xiong Y, et al. Cancer Med, 2018 Sep. PMID 30105866, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our study indicated that HOXB13-AS1 could regulate HOXB13 gene expression by methylation HOXB13 promoter and acts as an epigenetic oncogenic in glioma.
    Title: Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma.
  2. PRAC2 may have a function in prostate growth and development(PRAC2)
    Title: PRAC2: a new gene expressed in human prostate and prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative protein PRAC2
Names
HOXB cluster antisense RNA 5
prostate cancer susceptibility candidate 2
prostate, rectum and colon 2
prostate, rectum and colon expressed gene 2 protein
prostate, rectum and colon expressed gene protein 2
putative protein PRCA2
small nuclear protein PRAC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282275.2 → NP_001269204.1  putative protein PRAC2 isoform b precursor

    See identical proteins and their annotated locations for NP_001269204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF532777, AI201489, BX106051
    Consensus CDS
    CCDS74100.1
    UniProtKB/Swiss-Prot
    D3DTV9
    Related
    ENSP00000481367.1, ENST00000422730.4

  2. NM_001282276.1 → NP_001269205.1  putative protein PRAC2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI201489, AI762586, BX106051
    Consensus CDS
    CCDS74099.1
    UniProtKB/TrEMBL
    A0A087X2F6
    Related
    ENSP00000484945.1, ENST00000432056.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    48718666..48724758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435918.1 → XP_047291874.1  putative protein PRAC2 isoform X1

    UniProtKB/Swiss-Prot
    D3DTV9

  2. XM_011524747.2 → XP_011523049.1  putative protein PRAC2 isoform X1

    See identical proteins and their annotated locations for XP_011523049.1

    UniProtKB/Swiss-Prot
    D3DTV9

  3. XM_011524748.1 → XP_011523050.1  putative protein PRAC2 isoform X1

    See identical proteins and their annotated locations for XP_011523050.1

    UniProtKB/Swiss-Prot
    D3DTV9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    49582267..49588359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315954.1 → XP_054171929.1  putative protein PRAC2 isoform X1

    UniProtKB/Swiss-Prot
    D3DTV9

  2. XM_054315952.1 → XP_054171927.1  putative protein PRAC2 isoform X1

    UniProtKB/Swiss-Prot
    D3DTV9

  3. XM_054315953.1 → XP_054171928.1  putative protein PRAC2 isoform X1

    UniProtKB/Swiss-Prot
    D3DTV9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3DTV9.1 GenPept UniProtKB/Swiss-Prot:D3DTV9

Gene LinkOut

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