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sqa spaghetti-squash activator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36002, updated on 2-Nov-2024

Summary

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Official Symbol
sqaprovided by FlyBase
Official Full Name
spaghetti-squash activatorprovided by FlyBase
Primary source
FLYBASE:FBgn0259678
Locus tag
Dmel_CG42347
See related
AllianceGenome:FB:FBgn0259678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1776; CG30004; CG42347; Dmel\CG42347; FBgn0259678; Sqa
Old locus tag
Dmel_CG1776; Dmel_CG30004
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including compartment boundary maintenance; eye-antennal disc morphogenesis; and positive regulation of TOR signaling. Predicted to be active in cytoplasm. Is expressed in larval muscle system and larval somatic muscle cell. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to several human genes including MYLK3 (myosin light chain kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See sqa in Genome Data Viewer
Location:
46B1-46B2; 2-61 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9716348..9748121, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5603853..5635626, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44292 Neighboring gene uncharacterized protein Neighboring gene dacapo Neighboring gene Chemosensory protein A 46a Neighboring gene transient receptor potential-like Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. Champagne MB, et al. J Mol Biol, 2000 Jul 21. PMID 10891286
  2. Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Neubueser D, et al. Mol Biol Cell, 2010 Aug 15. PMID 20573980, Free PMC Article
  3. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Findlay GM, et al. Biochem J, 2007 Apr 1. PMID 17253963, Free PMC Article
  4. Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy. Tang HW, et al. EMBO J, 2011 Feb 16. PMID 21169990, Free PMC Article
  5. Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Xu J, et al. Dev Cell, 2018 Aug 6. PMID 30032991, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compartment boundary maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye-antennal disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelial fold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TOR signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
spaghetti-squash activator
Names
CG42347-PB
CG42347-PC
CG42347-PD
MLCK-like
sqa-PB
sqa-PC
sqa-PD
NP_001260832.1
NP_610514.1
NP_724821.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9716348..9748121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273903.2 → NP_001260832.1  spaghetti-squash activator, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Y7
    Conserved Domains (2) summary
    smart00220
    Location:34 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14103
    Location:40 → 289
    STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

  2. NM_165693.4 → NP_724821.2  spaghetti-squash activator, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724821.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Y7
    Conserved Domains (2) summary
    smart00220
    Location:34 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14103
    Location:40 → 289
    STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

  3. NM_136670.3 → NP_610514.1  spaghetti-squash activator, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610514.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SK9
    Related
    FBpp0289206
    Conserved Domains (2) summary
    smart00220
    Location:34 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14103
    Location:40 → 289
    STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7Y7 A1Z7Y7
Q95SK9 Q95SK9

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