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Uba1 Ubiquitin activating enzyme 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35998, updated on 2-Nov-2024

Summary

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Official Symbol
Uba1provided by FlyBase
Official Full Name
Ubiquitin activating enzyme 1provided by FlyBase
Primary source
FLYBASE:FBgn0023143
Locus tag
Dmel_CG1782
See related
AllianceGenome:FB:FBgn0023143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2/31; CG1782; Dmel\CG1782; DmUba1; E1; FBtr0088499; l(2)03405; l(2)05642; l(2)s3484; Uba; Uba 1; uba-1; UBA-1; uba1; UBA1
Summary
Enables ubiquitin activating enzyme activity. Involved in several processes, including larval midgut cell programmed cell death; mitophagy; and nervous system development. Located in dendrite. Is expressed in several structures, including CNS glial cell; ganglia; gut section; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Uba1 in Genome Data Viewer
Location:
46A1-46A1; 2-61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9688289..9693328, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5575794..5580833, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Matrix metalloproteinase 2 Neighboring gene long non-coding RNA:CR44070 Neighboring gene transfer RNA:initiator Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Curbing the excesses of youth: molecular insights into axonal pruning. Kantor DB, et al. Neuron, 2003 Jun 19. PMID 12818170
  2. Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment. Liu HY, et al. PLoS One, 2013. PMID 23382794, Free PMC Article
  3. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Page-McCaw A, et al. Dev Cell, 2003 Jan. PMID 12530966
  4. Establishment of a novel axon pruning model of Drosophila motor neuron. Xu W, et al. Biol Open, 2023 Jan 1. PMID 36606515, Free PMC Article
  5. Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure. Martin CA, et al. Neurotoxicology, 2014 Sep. PMID 25160001, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uba1, the E1 enzyme used in ubiquitylation, is required for autophagy and reduction of cell size.
    Title: Uba1 functions in Atg7- and Atg3-independent autophagy.
  2. These mutants of the E1, the ubiquitin activating enzyme exhibited further reduced lifespan and severe motor impairment.
    Title: Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.
  3. knockdown of SUMO or its E1 and E2 enzymes robustly disrupts proliferating cells in the developing eye, without any detectable effects on the development or differentiation of neighboring post-mitotic cells
    Title: A differential requirement for SUMOylation in proliferating and non-proliferating cells during Drosophila development.
  4. Data demonstrate that maintaining sufficient E1 function is required both cell autonomously and non-cell autonomously to prevent inappropriate Ras-ERK-dependent growth and proliferation in vivo.
    Title: Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo.
  5. This study showed that a reduction in uba1 activity can promote tissue growth in a multicellular organism and raise the possibility that changes in uba1 activity may occur during normal development or in cancer.
    Title: Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.
  6. phenotypic analysis of Uba1 demonstrates that impaired ubiquitin conjugation has significant consequences for the organism
    Title: The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval midgut cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
ubiquitin activating enzyme 1
Names
CG1782-PA
CG1782-PC
E1
E1 ligase
Uba1-PA
Uba1-PC
ubiquitin activating enzyme
ubiquitin-activating enzyme (E1)
NP_001260831.1
NP_477310.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9688289..9693328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057962.5 → NP_477310.2  ubiquitin activating enzyme 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477310.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46111, Q8T0L3, Q9V5A7
    Related
    FBpp0087583
    Conserved Domains (4) summary
    cd01490
    Location:606 → 1144
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:199 → 574
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:194 → 1188
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:447 → 510
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

  2. NM_001273902.1 → NP_001260831.1  ubiquitin activating enzyme 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260831.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF46, O46111
    Conserved Domains (4) summary
    cd01490
    Location:423 → 961
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:16 → 391
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:11 → 1005
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:264 → 327
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF46 A0A0B4KF46
O46111 O46111
Q8T0L3 Q8T0L3

Gene LinkOut

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