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IL13RA2 interleukin 13 receptor subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 3598, updated on 5-Mar-2024

Summary

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Official Symbol
IL13RA2provided by HGNC
Official Full Name
interleukin 13 receptor subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:5975
See related
Ensembl:ENSG00000123496 MIM:300130; AllianceGenome:HGNC:5975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT19; IL-13R; IL13BP; CD213A2
Summary
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 16.6), appendix (RPKM 2.7) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
Xq23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (115003982..115017616, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (113412686..113451239, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114238545..114252179, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 2C Neighboring gene uncharacterized LOC105373313 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 7 Neighboring gene microRNA 448 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:114140926-114142125 Neighboring gene RNA, U6 small nuclear 648, pseudogene Neighboring gene zinc finger protein 670 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models. Nagai T, et al. Cancer Rep (Hoboken), 2023 Feb. PMID 36806727, Free PMC Article
  2. IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases. Márquez-Ortiz RA, et al. Clin Cancer Res, 2021 Nov 15. PMID 34544797, Free PMC Article
  3. IL-13Rα2 gene expression is a biomarker of adverse outcome in patients with adrenocortical carcinoma. Kumar A, et al. PLoS One, 2021. PMID 33591997, Free PMC Article
  4. Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts. Penke LR, et al. Sci Rep, 2020 Jan 23. PMID 31974428, Free PMC Article
  5. Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation. Wang M, et al. FEBS Open Bio, 2020 Feb. PMID 31823484, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.
    Title: IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.
  2. Identification of the alpha2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models.
    Title: Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models.
  3. IL13Ralpha2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.
    Title: IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.
  4. Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation.
    Title: Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation.
  5. IL13Ralpha2 and EGFRtargeted pseudomonas exotoxin potentiates the TRAILmediated death of GBM cells.
    Title: IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells.
  6. Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
    Title: Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
  7. M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
    Title: M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
  8. IL-13Ralpha2 gene expression is a biomarker of adverse outcome in patients with adrenocortical carcinoma.
    Title: IL-13Rα2 gene expression is a biomarker of adverse outcome in patients with adrenocortical carcinoma.
  9. Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.
    Title: Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.
  10. Transcriptional regulation of the IL-13Ralpha2 gene in human lung fibroblasts.
    Title: Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-13 receptor subunit alpha-2
Names
IL-13 receptor subunit alpha-2
IL-13R subunit alpha-2
IL-13R-alpha-2
IL-13RA2
cancer/testis antigen 19
interleukin 13 binding protein
interleukin 13 receptor alpha 2 chain
interleukin 13 receptor, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012514.1 RefSeqGene

    Range
    5029..18663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000640.3 → NP_000631.1  interleukin-13 receptor subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_000631.1

    Status: REVIEWED

    Source sequence(s)
    Y08768
    Consensus CDS
    CCDS14565.1
    UniProtKB/Swiss-Prot
    A8K7E2, O00667, Q14627
    Related
    ENSP00000243213.1, ENST00000243213.2
    Conserved Domains (1) summary
    pfam09240
    Location:142 → 235
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    115003982..115017616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    113412686..113451239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327032.1 → XP_054183007.1  interleukin-13 receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7E2, O00667, Q14627

  2. XM_054327033.1 → XP_054183008.1  interleukin-13 receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    A8K7E2, O00667, Q14627
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14627.1 GenPept UniProtKB/Swiss-Prot:Q14627

Gene LinkOut

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