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Pdk Pyruvate dehydrogenase kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35970, updated on 18-Sep-2024

Summary

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Official Symbol
Pdkprovided by FlyBase
Official Full Name
Pyruvate dehydrogenase kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0017558
Locus tag
Dmel_CG8808
See related
AllianceGenome:FB:FBgn0017558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD09837; CG8808; Dmel\CG8808; DmPdk; DmPDK; PDHK; pdk; PDK
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in protein phosphorylation and regulation of glucose metabolic process. Predicted to be part of mitochondrial pyruvate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to several human genes including PDK1 (pyruvate dehydrogenase kinase 1); PDK2 (pyruvate dehydrogenase kinase 2); and PDK3 (pyruvate dehydrogenase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pdk in Genome Data Viewer
Location:
45D5-45D7; 2-60 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9426439..9434638)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5313944..5322143)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene preli-like Neighboring gene ced-6 Neighboring gene long non-coding RNA:CR45321

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA sequence and expression of a gene encoding a pyruvate dehydrogenase kinase homolog of Drosophila melanogaster. Katsube T, et al. DNA Cell Biol, 1997 Mar. PMID 9115642
  2. Pyruvate Dehydrogenase Kinase Protects Dopaminergic Neurons from Oxidative Stress in Drosophila DJ-1 Null Mutants. Lee Y, et al. Mol Cells, 2022 Jul 31. PMID 35444068, Free PMC Article
  3. CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases. Lambrechts RA, et al. EMBO Mol Med, 2019 Dec. PMID 31701655, Free PMC Article
  4. Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae. George J, et al. Fly (Austin), 2019 Mar-Dec. PMID 31526131, Free PMC Article
  5. Patterning of the Drosophila L2 vein is driven by regulatory interactions between region-specific transcription factors expressed in response to Dpp signalling. Martín M, et al. Development, 2017 Sep 1. PMID 28760811

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase kinase
Names
CG8808-PA
CG8808-PB
CG8808-PC
CG8808-PD
Pdk-PA
Pdk-PB
Pdk-PC
Pdk-PD
NP_001097240.1
NP_001246224.1
NP_001260825.1
NP_477215.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9426439..9434638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273896.1 → NP_001260825.1  pyruvate dehydrogenase kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFG2
    Conserved Domains (2) summary
    cd16929
    Location:197 → 366
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:32 → 193
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. NM_001103770.2 → NP_001097240.1  pyruvate dehydrogenase kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097240.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY78
    Conserved Domains (2) summary
    cd16929
    Location:197 → 366
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:32 → 193
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. NM_001259295.2 → NP_001246224.1  pyruvate dehydrogenase kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246224.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91622, Q9V580
    UniProtKB/TrEMBL
    A0A0B4K7V5
    Conserved Domains (3) summary
    smart00387
    Location:244 → 366
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:197 → 374
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:32 → 193
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. NM_057867.4 → NP_477215.1  pyruvate dehydrogenase kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477215.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91622, Q9V580
    UniProtKB/TrEMBL
    A0A0B4K7V5
    Related
    FBpp0087592
    Conserved Domains (3) summary
    smart00387
    Location:244 → 366
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:197 → 374
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:32 → 193
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7V5 A0A0B4K7V5
A0A0B4KFG2 A0A0B4KFG2
A8DY78 A8DY78
P91622.2 P91622

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