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CNT1 Concentrative nucleoside transporter 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35915, updated on 2-Nov-2024

Summary

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Official Symbol
CNT1provided by FlyBase
Official Full Name
Concentrative nucleoside transporter 1provided by FlyBase
Primary source
FLYBASE:FBgn0033371
Locus tag
Dmel_CG11778
See related
AllianceGenome:FB:FBgn0033371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11778; cnt1; DmCnt1; Dmel\CG11778
Summary
Predicted to enable nucleoside:sodium symporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; late elongation-stage spermatid; mid-late elongation-stage spermatid; and testis. Orthologous to human SLC28A1 (solute carrier family 28 member 1); SLC28A2 (solute carrier family 28 member 2); and SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CNT1 in Genome Data Viewer
Location:
45A1-45A1; 2-60 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9082395..9085717)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4969900..4973222)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene anachronism Neighboring gene antisense RNA:CR45924 Neighboring gene Concentrative nucleoside transporter 2 Neighboring gene uncharacterized protein Neighboring gene DEAD box protein 45A Neighboring gene NAD kinase 2, mitochondrial Neighboring gene Bootlegger

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation in Drosophila concentrative nucleoside transporter 1 alters spermatid maturation and mating behavior. Maaroufi HO, et al. Front Cell Dev Biol, 2022. PMID 36105362, Free PMC Article
  2. Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter. Machado J, et al. Physiol Genomics, 2007 Feb 12. PMID 17090699
  3. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. Knight D, et al. J Neurosci, 2010 Apr 7. PMID 20371825, Free PMC Article
  4. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
  5. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
concentrative nucleoside transporter 1
Names
CG11778-PB
CNT1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9082395..9085717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136603.3 → NP_610447.2  concentrative nucleoside transporter 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610447.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7N3, B3DN99
    Conserved Domains (4) summary
    TIGR00804
    Location:184 → 581
    nupC; nucleoside transporter
    pfam01773
    Location:188 → 257
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:372 → 581
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:271 → 366
    Gate; Nucleoside recognition
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7N3 A1Z7N3

Gene LinkOut

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