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CG13743 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35911, updated on 2-Nov-2024

Summary

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Official Symbol
CG13743provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033368
Locus tag
Dmel_CG13743
See related
AllianceGenome:FB:FBgn0033368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG13743
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in membrane. Is expressed in adult abdomen; adult head; and adult thorax. Orthologous to human SLC38A11 (solute carrier family 38 member 11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG13743 in Genome Data Viewer
Location:
45A1-45A1; 2-60 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9044850..9060608, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4932355..4948113, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ance-4 Neighboring gene Prophenoloxidase 2 Neighboring gene uncharacterized protein Neighboring gene anachronism Neighboring gene antisense RNA:CR45924 Neighboring gene Concentrative nucleoside transporter 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knockdown of SLC38 Transporter Ortholog - CG13743 Reveals a Metabolic Relevance in Drosophila. Aggarwal T, et al. Front Physiol, 2019. PMID 32038282, Free PMC Article
  2. Prophenoloxidase activation is required for survival to microbial infections in Drosophila. Binggeli O, et al. PLoS Pathog, 2014 May. PMID 24788090, Free PMC Article
  3. Metabolite transport across the mammalian and insect brain diffusion barriers. Weiler A, et al. Neurobiol Dis, 2017 Nov. PMID 28237316
  4. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Han Y, et al. Elife, 2017 Aug 14. PMID 28806173, Free PMC Article
  5. A post-ingestive amino acid sensor promotes food consumption in Drosophila. Yang Z, et al. Cell Res, 2018 Oct. PMID 30209352, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG13743-PA
CG13743-PB
CG13743-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9044850..9060608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299295.1 → NP_001286224.1  uncharacterized protein Dmel_CG13743, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286224.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEY7
    Conserved Domains (1) summary
    cl00456
    Location:75 → 245
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001259285.2 → NP_001246214.1  uncharacterized protein Dmel_CG13743, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7V2
    Conserved Domains (1) summary
    cl00456
    Location:75 → 480
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_136600.2 → NP_610444.2  uncharacterized protein Dmel_CG13743, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610444.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRD1, Q9V522
    Related
    FBpp0087743
    Conserved Domains (2) summary
    COG0814
    Location:95 → 491
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:95 → 500
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7V2 A0A0B4K7V2
A0A0B4LEY7 A0A0B4LEY7
Q8MRD1 Q8MRD1

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