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Ance-4 Ance-4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35909, updated on 2-Nov-2024

Summary

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Official Symbol
Ance-4provided by FlyBase
Official Full Name
Ance-4provided by FlyBase
Primary source
FLYBASE:FBgn0033366
Locus tag
Dmel_CG8196
See related
AllianceGenome:FB:FBgn0033366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ance-4; CG8196; Dmel\CG8196
Summary
Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in amnioserosa; embryonic/larval crystal cell; and procrystal cell. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ance-4 in Genome Data Viewer
Location:
45A1-45A1; 2-60 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9039728..9042142, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4927233..4929647, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Prophenoloxidase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ACE and ACE2: insights from Drosophila and implications for COVID-19. Herrera P, et al. Heliyon, 2021 Dec. PMID 34901515, Free PMC Article
  2. A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila. Yamada T, et al. Nat Metab, 2020 Oct. PMID 33046910
  3. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme. Coates D, et al. Biochemistry, 2000 Aug 1. PMID 10913309
  4. The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Vodala S, et al. Cell Metab, 2012 Nov 7. PMID 23122660, Free PMC Article
  5. dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes. Korenjak M, et al. Nucleic Acids Res, 2014 Aug. PMID 25053843, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables metallopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables peptidyl-dipeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in proteolysis IKR
Inferred from Key Residues
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ance-4
Names
Ance-4-PA
Ance-4-PB
CG8196-PA
CG8196-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9039728..9042142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136598.3 → NP_610442.2  Ance-4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610442.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7M8, Q8MS05
    Related
    FBpp0087745
    Conserved Domains (1) summary
    cl14813
    Location:25 → 601
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  2. NM_001299294.1 → NP_001286223.1  Ance-4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEH6, Q8MS05
    Conserved Domains (1) summary
    cl14813
    Location:60 → 506
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEH6 A0A0B4LEH6
A1Z7M8 A1Z7M8
Q8MS05 Q8MS05

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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