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CG8170 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35908, updated on 2-Nov-2024

Summary

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Official Symbol
CG8170provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033365
Locus tag
Dmel_CG8170
See related
AllianceGenome:FB:FBgn0033365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cSP54; Dmel\CG8170; SP54
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS22 (serine protease 22) and PRSS41 (serine protease 41). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG8170 in Genome Data Viewer
Location:
45A1-45A1; 2-60 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9019032..9031045, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4906537..4918550, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ance-4 Neighboring gene Prophenoloxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
  2. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
  3. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670
  4. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
  5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG8170-PA
CG8170-PB
NP_001036533.1
NP_610441.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9019032..9031045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136597.4 → NP_610441.2  uncharacterized protein Dmel_CG8170, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610441.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7M7
    Conserved Domains (2) summary
    smart00020
    Location:611 → 845
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:612 → 846
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001043068.2 → NP_001036533.1  uncharacterized protein Dmel_CG8170, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZK6
    Conserved Domains (2) summary
    smart00020
    Location:534 → 768
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:535 → 769
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7M7 A1Z7M7
Q7JZK6 Q7JZK6

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