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CG8172 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35905, updated on 2-Nov-2024

Summary

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Official Symbol
CG8172provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033362
Locus tag
Dmel_CG8172
See related
AllianceGenome:FB:FBgn0033362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-SP32; cSP32; Dmel\CG8172; SP32
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in dorsal sensory complex proper primordium; embryonic/larval posterior spiracle; and posterior spiracle primordium. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG8172 in Genome Data Viewer
Location:
45A1-45A1; 2-60 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9007234..9013526, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4894739..4901031, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene filzig Neighboring gene Notopleural Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic evidence of a redox-dependent systemic wound response via Hayan protease-phenoloxidase system in Drosophila. Nam HJ, et al. EMBO J, 2012 Mar 7. PMID 22227521, Free PMC Article
  2. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
  3. Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. Seong KM, et al. Biogerontology, 2011 Apr. PMID 20617381
  4. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
  5. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG8172-PD
CG8172-PE
CG8172-PF
CG8172-PG
NP_001097235.2
NP_001097236.2
NP_001286222.1
NP_610438.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9007234..9013526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103766.3 → NP_001097236.2  uncharacterized protein Dmel_CG8172, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097236.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY74, Q8MS52
    Conserved Domains (2) summary
    smart00020
    Location:125 → 362
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:126 → 365
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_136594.4 → NP_610438.2  uncharacterized protein Dmel_CG8172, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610438.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7M4
    Conserved Domains (2) summary
    smart00020
    Location:299 → 536
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:300 → 539
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_001103765.2 → NP_001097235.2  uncharacterized protein Dmel_CG8172, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097235.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY75
    Conserved Domains (2) summary
    smart00020
    Location:315 → 552
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:316 → 555
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. NM_001299293.1 → NP_001286222.1  uncharacterized protein Dmel_CG8172, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEW8
    Conserved Domains (2) summary
    smart00020
    Location:1 → 183
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:1 → 186
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEW8 A0A0B4LEW8
A1Z7M4 A1Z7M4
A8DY75 A8DY75
Q8MS52 Q8MS52

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