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babo baboon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35900, updated on 2-Nov-2024

Summary

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Official Symbol
baboprovided by FlyBase
Official Full Name
baboonprovided by FlyBase
Primary source
FLYBASE:FBgn0011300
Locus tag
Dmel_CG8224
See related
AllianceGenome:FB:FBgn0011300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Atf1; Atr-1; ATR-1; atr-I; Atr-I; ATR-I; Atr45A; AtrI; Bab; Babo; BABO; BaboA; Baboon; CG8224; Dmel\CG8224; Gprk-3; Gprk3; l(2)44Fd; l(2)k16912; STK-E
Summary
Enables activin binding activity and activin receptor activity, type I. Involved in several processes, including determination of adult lifespan; imaginal disc morphogenesis; and nervous system development. Located in plasma membrane. Part of activin receptor complex. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval gut; female germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); gastrointestinal system cancer (multiple); and malignant mesothelioma. Orthologous to human ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See babo in Genome Data Viewer
Location:
44F11-44F12; 2-59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8952339..8962796)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4839844..4850301)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Translocase of outer membrane 7 Neighboring gene space blanket Neighboring gene filzig

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex. Wrana JL, et al. Mol Cell Biol, 1994 Feb. PMID 8289834, Free PMC Article
  2. Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster. Ghosh AC, et al. Proc Natl Acad Sci U S A, 2014 Apr 15. PMID 24706779, Free PMC Article
  3. Multiple isoforms of the Activin-like receptor baboon differentially regulate proliferation and conversion behaviors of neuroblasts and neuroepithelial cells in the Drosophila larval brain. Lee GG, et al. PLoS One, 2024. PMID 38913612, Free PMC Article
  4. Drosophila activins adapt gut size to food intake and promote regenerative growth. Christensen CF, et al. Nat Commun, 2024 Jan 4. PMID 38177201, Free PMC Article
  5. Developmentally programmed remodeling of the Drosophila olfactory circuit. Marin EC, et al. Development, 2005 Feb. PMID 15659487

See all (222) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Visualization of Endogenous Type I TGF-beta Receptor Baboon in the Drosophila Brain.
    Title: Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.
  2. Data show that dSmad2 directly influences Baboon's phosphorylation of Mad.
    Title: R-Smad competition controls activin receptor output in Drosophila.
  3. Study shows that the Daw/Babo pathway acts upstream of gbb, and is involved in maintenance of muscle gbb expression.
    Title: Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction.
  4. Dawdle, one of four Activin-type ligands in Drosophila, preferentially signals through Babo(c), one of three isoforms of the Activin Type-I receptor that are expressed during development.
    Title: The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon.
  5. Dad inhibited Saxophone and Thickveins but not Baboon.
    Title: Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.
  6. Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis.
    Title: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables activin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables activin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin receptor activity, type I IDA
Inferred from Direct Assay
more info
 PubMed 
enables activin receptor activity, type I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in activin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite morphogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_positive_effect determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye-antennal disc morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of imaginal disc-derived wing size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of activin receptor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
baboon
Names
CG8224-PA
CG8224-PB
CG8224-PC
G protein-coupled receptor kinase 3
activin A receptor 45A
activin type I receptor
babo
babo-PA
babo-PB
babo-PC
baboa
NP_001163092.1
NP_476999.1
NP_477000.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8952339..8962796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057651.4 → NP_476999.1  baboon, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476999.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7L8, Q23975
    Related
    FBpp0087739
    Conserved Domains (4) summary
    smart00467
    Location:294 → 324
    GS; GS motif
    cd14143
    Location:328 → 615
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:127 → 214
    Activin_recp; Activin types I and II receptor domain
    pfam07714
    Location:324 → 611
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_057652.4 → NP_477000.1  baboon, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7L9, Q23975
    Related
    FBpp0087740
    Conserved Domains (4) summary
    smart00467
    Location:273 → 303
    GS; GS motif
    cd14143
    Location:307 → 594
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:127 → 204
    Activin_recp; Activin types I and II receptor domain
    pfam07714
    Location:303 → 590
    Pkinase_Tyr; Protein tyrosine kinase

  3. NM_001169621.2 → NP_001163092.1  baboon, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163092.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23975, Q7YU60
    Conserved Domains (4) summary
    smart00467
    Location:267 → 297
    GS; GS motif
    cd14143
    Location:301 → 588
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:127 → 196
    Activin_recp; Activin types I and II receptor domain
    pfam07714
    Location:297 → 584
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7L8 A1Z7L8
A1Z7L9 A1Z7L9
Q23975 Q23975
Q7YU60 Q7YU60

Gene LinkOut

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