Pgi Phosphoglucose isomerase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pgiprovided by FlyBase
Official Full Name: Phosphoglucose isomeraseprovided by FlyBase
Primary source: FLYBASE:FBgn0003074
Locus tag: Dmel_CG8251
See related: AllianceGenome:FB:FBgn0003074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8251; Dmel\CG8251; DmG6PI; gpi; Gpi; GPI; pgi; PGI
Summary: Enables glucose-6-phosphate isomerase activity. Involved in several processes, including canonical glycolysis; fructose 6-phosphate metabolic process; and glucose 6-phosphate metabolic process. Located in cytosol. Is expressed in several structures, including adult head; adult heart; larval muscle system; larval somatic muscle cell; and spermatozoon. Used to study heart disease. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 44F6-44F6; 2-59 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8910900..8914069, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4798405..4801574, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fructose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoglucose isomerase

Names: CG8251-PA; CG8251-PB; CG8251-PC; Glucose-6-phosphate isomerase; Pgi-PA; Pgi-PB; Pgi-PC; glucose phosphate isomerase; phosphoglucoisomerase

NP_523663.1

EC 5.3.1.9

NP_724723.1

EC 5.3.1.9

NP_724724.1

EC 5.3.1.9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8910900..8914069 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165635.2 → NP_724723.1 phosphoglucose isomerase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ93, P52029, Q0E9F0, Q27868, Q27870, Q9V4Z8

Related

FBpp0087761

Conserved Domains (3) summary

PRK00179
Location:7 → 556

pgi; glucose-6-phosphate isomerase; Reviewed

cd05015
Location:128 → 290

SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

cd05016
Location:338 → 529

SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
NM_078939.3 → NP_523663.1 phosphoglucose isomerase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523663.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ93, P52029, Q0E9F0, Q27868, Q27870, Q9V4Z8

Related

FBpp0087760

Conserved Domains (3) summary

PRK00179
Location:7 → 556

pgi; glucose-6-phosphate isomerase; Reviewed

cd05015
Location:128 → 290

SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

cd05016
Location:338 → 529

SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
NM_165636.2 → NP_724724.1 phosphoglucose isomerase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724724.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ93, P52029, Q0E9F0, Q27868, Q27870, Q9V4Z8

Related

FBpp0087762

Conserved Domains (3) summary

PRK00179
Location:7 → 556

pgi; glucose-6-phosphate isomerase; Reviewed

cd05015
Location:128 → 290

SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

cd05016
Location:338 → 529

SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...