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IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 3588, updated on 11-Apr-2024

Summary

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Official Symbol
IL10RBprovided by HGNC
Official Full Name
interleukin 10 receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:5965
See related
Ensembl:ENSG00000243646 MIM:123889; AllianceGenome:HGNC:5965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRFB4; IBD25; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB
Summary
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more
Orthologs
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Genomic context

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See IL10RB in Genome Data Viewer
Location:
21q22.11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33266367..33310182)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31635162..31678970)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638672..34669526)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13249 Neighboring gene IFNAR2-IL10RB readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18370 Neighboring gene NANOG hESC enhancer GRCh37_chr21:34617736-34618335 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18374 Neighboring gene IL10RB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34676441-34676940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13255 Neighboring gene IFNAR1 promoter region Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14728 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:34738709-34739908 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:34752348-34753547 Neighboring gene Sharpr-MPRA regulatory region 6397 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:34758349-34758554 Neighboring gene IFNGR2 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13259 Neighboring gene CRISPRi-FlowFISH-validated IFNGR2 regulatory element GRCh37_chr21:34776289-34777452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34784507-34785261 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:34785395-34785563 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9. Luo S, et al. J Alzheimers Dis, 2022. PMID 35811529
  2. Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds. Charbit-Henrion F, et al. PLoS One, 2018. PMID 30365510, Free PMC Article
  3. Polymorphism of IL-10 receptor β affects the prognosis of multiple myeloma patients treated with thalidomide and/or bortezomib. Kasamatsu T, et al. Hematol Oncol, 2017 Dec. PMID 27405747
  4. IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis. Khare V, et al. Cancer Immunol Res, 2015 Nov. PMID 26130064
  5. IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population. Peng H, et al. Inflammation, 2013 Dec. PMID 23749100

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
    Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
  2. Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.
    Title: Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.
  3. Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students.
    Title: Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students.
  4. Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.
    Title: Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.
  5. IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
    Title: IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
  6. Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.
    Title: Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.
  7. Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.
    Title: Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.
  8. analysis of two novel copy number variations in IL10RB, one with founder effect and one preserving cell surface expression but abolishing signaling
    Title: Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds.
  9. IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2.
    Title: IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.
  10. We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations.
    Title: Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hepatitis B virus, susceptibility to
MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
Compare labs
Inflammatory bowel disease 25
MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: IFNAR2

Readthrough IFNAR2-IL10RB

Readthrough gene: IFNAR2-IL10RB, Included gene: IFNAR2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-10 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to interleukin-10 receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to virus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in type III interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of interleukin-28 receptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-10 receptor subunit beta
Names
IL-10 receptor subunit beta
IL-10R subunit 2
IL-10R subunit beta
cytokine receptor class-II CRF2-4
cytokine receptor class-II member 4
cytokine receptor family 2 member 4
cytokine receptor family II, member 4
interleukin 10 receptor, beta
interleukin-10 receptor subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012089.1 RefSeqGene

    Range
    4994..35868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

mRNA and Protein(s)

  1. NM_000628.5 → NP_000619.3  interleukin-10 receptor subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_000619.3

    Status: REVIEWED

    Source sequence(s)
    AI025402, AU133530, BC001903, Z17227
    Consensus CDS
    CCDS13623.1
    UniProtKB/Swiss-Prot
    Q08334, Q9BUU4
    UniProtKB/TrEMBL
    H2DF06
    Related
    ENSP00000290200.2, ENST00000290200.7
    Conserved Domains (2) summary
    pfam09294
    Location:111 → 213
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:21 → 100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001405849.1 → NP_001392778.1  interleukin-10 receptor subunit beta isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000295
    UniProtKB/TrEMBL
    A0A1B0GTI5
    Related
    ENSP00000489716.2, ENST00000637650.2

  3. NM_001405850.1 → NP_001392779.1  interleukin-10 receptor subunit beta isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000295
    UniProtKB/TrEMBL
    A0A1B0GU52
    Related
    ENSP00000489965.2, ENST00000609556.3

  4. NM_001406840.1 → NP_001393769.1  interleukin-10 receptor subunit beta isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000295

RNA

  1. NR_175973.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000295

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    33266367..33310182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    31635162..31678970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08334.2 GenPept UniProtKB/Swiss-Prot:Q08334

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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