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Mal-A2 Maltase A2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35825, updated on 2-Nov-2024

Summary

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Official Symbol
Mal-A2provided by FlyBase
Official Full Name
Maltase A2provided by FlyBase
Primary source
FLYBASE:FBgn0002569
Locus tag
Dmel_CG8694
See related
AllianceGenome:FB:FBgn0002569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8694; D; Dmel\CG8694; Drome_A2; lvpD; LvpD; mal_A2
Summary
Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Mal-A2 in Genome Data Viewer
Location:
44D1-44D1; 2-59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8453627..8455782)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4341132..4343287)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop Neighboring gene Cytochrome P450 4e1 Neighboring gene Maltase A1 Neighboring gene Maltase A3 Neighboring gene Maltase A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two gene families clustered in a small region of the Drosophila genome. Snyder M, et al. J Mol Biol, 1983 May 15. PMID 6854639
  2. The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster. Vieira CP, et al. Mol Biol Evol, 1997 Oct. PMID 9335139
  3. Exposure to Titanium Dioxide Nanoparticles Leads to Specific Disorders of Spermatid Elongation via Multiple Metabolic Pathways in Drosophila Testes. Cheng X, et al. ACS Omega, 2024 Jun 4. PMID 38854533, Free PMC Article
  4. Detection of protein similarities using nucleotide sequence databases. Henikoff S, et al. Nucleic Acids Res, 1988 Jul 11. PMID 3135536, Free PMC Article
  5. Comparative Transcriptomic Analysis Revealing the Potential Mechanisms of Erythritol-Caused Mortality and Oviposition Inhibition in Drosophila melanogaster. Li L, et al. Int J Mol Sci, 2024 Mar 27. PMID 38612549, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maltase A2
Names
CG8694-PA
Mal-A2-PA
hdl cuticle gene cluster
larval visceral protein D
maltase
NP_476625.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8453627..8455782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057277.3 → NP_476625.2  maltase A2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476625.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07191, Q9V4T7
    Related
    FBpp0087826
    Conserved Domains (2) summary
    cd11328
    Location:24 → 484
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    pfam00128
    Location:50 → 405
    Alpha-amylase; Alpha amylase, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07191.2 P07191

Gene LinkOut

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