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CSN7 COP9 signalosome subunit 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35816, updated on 18-Sep-2024

Summary

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Official Symbol
CSN7provided by FlyBase
Official Full Name
COP9 signalosome subunit 7provided by FlyBase
Primary source
FLYBASE:FBgn0028836
Locus tag
Dmel_CG2038
See related
AllianceGenome:FB:FBgn0028836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2038; CH7; csn7; Csn7; CSN7b; Dch7; Dmel\CG2038
Summary
Involved in female germ-line stem cell population maintenance; gamete generation; and protein stabilization. Located in nuclear periphery. Part of COP9 signalosome. Is expressed in adult head. Orthologous to human COPS7A (COP9 signalosome subunit 7A) and COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CSN7 in Genome Data Viewer
Location:
44C6-44C6; 2-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8421033..8428577)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4308538..4316082)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Larval cuticle protein 1 Neighboring gene Larval cuticle protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development. Schwechheimer C. Biochim Biophys Acta, 2004 Nov 29. PMID 15571808
  2. COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis. Harari-Steinberg O, et al. Genes Cells, 2007 Feb. PMID 17295838
  3. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Gemmill RM, et al. Oncogene, 2005 May 12. PMID 15735686
  4. The COP9 signalosome is essential for development of Drosophila melanogaster. Freilich S, et al. Curr Biol, 1999 Oct 21. PMID 10531038
  5. Protein competition switches the function of COP9 from self-renewal to differentiation. Pan L, et al. Nature, 2014 Oct 9. PMID 25119050

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived cystoblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germ-line cyst encapsulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deneddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
part_of COP9 signalosome IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of COP9 signalosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
COP9 signalosome subunit 7
Names
CG2038-PA
COP9 complex homolog subunit 7
CSN7-PA
drosophila COP9 signalosome homolog 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8421033..8428577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136535.3 → NP_610379.2  COP9 signalosome subunit 7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610379.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NLA1, Q9V4S8
    UniProtKB/TrEMBL
    N0A733
    Related
    FBpp0087821
    Conserved Domains (1) summary
    smart00753
    Location:96 → 185
    PAM; PCI/PINT associated module
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V4S8.2 Q9V4S8

Gene LinkOut

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