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Nup50 Nucleoporin 50kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35784, updated on 2-Nov-2024

Summary

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Official Symbol
Nup50provided by FlyBase
Official Full Name
Nucleoporin 50kDprovided by FlyBase
Primary source
FLYBASE:FBgn0033264
Locus tag
Dmel_CG2158
See related
AllianceGenome:FB:FBgn0033264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2158; Dmel\CG2158; Nup; nup50; NUP50
Summary
Enables chromatin DNA binding activity. Involved in heat shock-mediated polytene chromosome puffing; positive regulation of transcription by RNA polymerase II; and protein import into nucleus. Located in chromatin and polytene chromosome band. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Used to study neurodegenerative disease. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Nup50 in Genome Data Viewer
Location:
44B2-44B3; 2-58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8123036..8125058)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4010541..4012563)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene under-developed Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain Neighboring gene coilin Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Pabp2 Neighboring gene Odorant-binding protein 44a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Megat S, et al. Nat Commun, 2023 Jan 20. PMID 36670122, Free PMC Article
  2. Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Kalverda B, et al. Cell, 2010 Feb 5. PMID 20144760
  3. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Chou CC, et al. Nat Neurosci, 2018 Feb. PMID 29311743, Free PMC Article
  4. Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome. Vaquerizas JM, et al. PLoS Genet, 2010 Feb 12. PMID 20174442, Free PMC Article
  5. From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression. Burns LT, et al. Mol Cell Biol, 2014 Jun. PMID 24615017, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heat shock-mediated polytene chromosome puffing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
located_in polytene chromosome band IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleoporin 50kD
Names
CG2158-PA
Nup50-PA
nuclear pore protein 50
nucleoporin 50

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8123036..8125058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136511.3 → NP_610355.1  nucleoporin 50kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610355.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K0D8
    Related
    FBpp0087861
    Conserved Domains (2) summary
    cd13170
    Location:453 → 563
    RanBD_NUP50; Nucleoporin 50 Ran-binding domain
    pfam08911
    Location:4 → 80
    NUP50; NUP50 (Nucleoporin 50 kDa)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0D8.1 Q7K0D8

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