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rnh1 ribonuclease H1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35746, updated on 22-Aug-2024

Summary

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Official Symbol
rnh1provided by FlyBase
Official Full Name
ribonuclease H1provided by FlyBase
Primary source
FLYBASE:FBgn0023171
Locus tag
Dmel_CG8729
See related
AllianceGenome:FB:FBgn0023171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
74/9; CG8729; Dmel\CG8729; l(2)43F1-5; l(2)43Fa; l(2)k07409; l(2)k07624; RNase H1; RnH1; rnhl
Summary
Enables RNA-DNA hybrid ribonuclease activity. Involved in mitochondrial DNA replication. Located in mitochondrion and nucleus. Is expressed in brain; central nervous system; embryonic/larval proventriculus; gonad; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
43F2-43F2; 2-57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7931054..7932380, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3818559..3819885, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X Neighboring gene drosha Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. R-loop Mapping and Characterization During Drosophila Embryogenesis Reveals Developmental Plasticity in R-loop Signatures. Munden A, et al. J Mol Biol, 2022 Jul 15. PMID 35609632, Free PMC Article
  2. Functional characterization of RNase H1 from Drosophila melanogaster. Filippov V, et al. Biochem Biophys Res Commun, 1997 Nov 26. PMID 9398656
  3. Drosophila RNase H1 is essential for development but not for proliferation. Filippov V, et al. Mol Genet Genomics, 2001 Jul. PMID 11523794
  4. A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. González de Cózar JM, et al. J Biochem, 2020 Nov 1. PMID 32589740, Free PMC Article
  5. Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Elmore T, et al. Insect Biochem Mol Biol, 2001 Jun 22. PMID 11378414

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. addition of FAT10 also led to an increased interaction between OTUB1 and its cognate E2 UbcH5B, implying a function of FAT10 in the inhibition of polyubiquitylation
    Title: RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA-DNA hybrid ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA-DNA hybrid ribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication, removal of RNA primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease H1
Names
CG8729-PA
CG8729-PB
RNaseH1
rnh1-PA
rnh1-PB
NP_477315.1
NP_995777.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7931054..7932380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206055.3 → NP_995777.1  ribonuclease H1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z768, O44114
    Conserved Domains (2) summary
    cd09280
    Location:164 → 307
    RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
    pfam01693
    Location:19 → 60
    Cauli_VI; Caulimovirus viroplasmin

  2. NM_057967.5 → NP_477315.1  ribonuclease H1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477315.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44114, Q7JY33
    Related
    FBpp0087959
    Conserved Domains (2) summary
    cd09280
    Location:183 → 326
    RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
    pfam01693
    Location:19 → 60
    Cauli_VI; Caulimovirus viroplasmin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z768 A1Z768
O44114 O44114
Q7JY33 Q7JY33

Gene LinkOut

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