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Cul1 Cullin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35742, updated on 2-Nov-2024

Summary

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Official Symbol
Cul1provided by FlyBase
Official Full Name
Cullin 1provided by FlyBase
Primary source
FLYBASE:FBgn0015509
Locus tag
Dmel_CG1877
See related
AllianceGenome:FB:FBgn0015509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1877; cul-1; Cul-1; cul1; CUL1; Cullin-1; Cullin1; dCul-1; dCul1; dCUL1; dmCUL1; Dmel\CG1877; l(2)02074; l(2)k01207; lin 19; Lin-19; lin-19/cul-1; lin19; Lin19; lin19-like; Q9V312
Summary
Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of protein metabolic process. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; imaginal disc; and mesoderm. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cul1 in Genome Data Viewer
Location:
43F1-43F2; 2-57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7916856..7921579)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3804361..3809084)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 10 Neighboring gene Diacyl glycerol kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 43b Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dysregulation of core components of SCF complex in poly-glutamine disorders. Bhutani S, et al. Cell Death Dis, 2012 Nov 22. PMID 23171848, Free PMC Article
  2. The F-Box Protein CG5003 Regulates Axon Pruning and the Integrity of the Drosophila Mushroom Body. Yang M, et al. Front Mol Neurosci, 2021. PMID 33716667, Free PMC Article
  3. Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Elmore T, et al. Insect Biochem Mol Biol, 2001 Jun 22. PMID 11378414
  4. The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity. Suisse A, et al. Fly (Austin), 2018. PMID 29355077, Free PMC Article
  5. COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch. Djagaeva I, et al. PLoS One, 2009 Oct 27. PMID 19859546, Free PMC Article

See all (173) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
    Title: CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
  2. mutant larvae accumulate high levels of non-neddylated Cul1, suggesting that Int6 is a positive regulator of cullin neddylation
    Title: The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
  3. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
    Title: Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase complex scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IC
Inferred by Curator
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cullin 1
Names
CG1877-PA
CG1877-PB
CG1877-PC
CG1877-PD
Cul1-PA
Cul1-PB
Cul1-PC
Cul1-PD
SCF-betaTrCP complex
cullin
cullin-1
cullin1
dCullin
dCullin1
lin-19-like
lin19-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7916856..7921579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165571.2 → NP_724623.1  cullin 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724623.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ78, Q0E9G0, Q24311, Q9V312
    UniProtKB/TrEMBL
    D3DMX2
    Related
    FBpp0087921
    Conserved Domains (3) summary
    smart00182
    Location:454 → 593
    CULLIN; Cullin
    smart00884
    Location:701 → 765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21 → 669
    Cullin; Cullin family

  2. NM_165570.3 → NP_724622.1  cullin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ78, Q0E9G0, Q24311, Q9V312
    UniProtKB/TrEMBL
    D3DMX2
    Related
    FBpp0087922
    Conserved Domains (3) summary
    smart00182
    Location:454 → 593
    CULLIN; Cullin
    smart00884
    Location:701 → 765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21 → 669
    Cullin; Cullin family

  3. NM_165569.2 → NP_724621.1  cullin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724621.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ78, Q0E9G0, Q24311, Q9V312
    UniProtKB/TrEMBL
    D3DMX2
    Related
    FBpp0087923
    Conserved Domains (3) summary
    smart00182
    Location:454 → 593
    CULLIN; Cullin
    smart00884
    Location:701 → 765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21 → 669
    Cullin; Cullin family

  4. NM_078931.4 → NP_523655.1  cullin 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523655.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ78, Q0E9G0, Q24311, Q9V312
    UniProtKB/TrEMBL
    D3DMX2
    Related
    FBpp0087924
    Conserved Domains (3) summary
    smart00182
    Location:454 → 593
    CULLIN; Cullin
    smart00884
    Location:701 → 765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21 → 669
    Cullin; Cullin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24311.2 Q24311

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