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CG1598 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35690, updated on 2-Nov-2024

Summary

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Official Symbol
CG1598provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033191
Locus tag
Dmel_CG1598
See related
AllianceGenome:FB:FBgn0033191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM18141; BEST:GH10483; Dmel\CG1598; gh10483
Summary
Predicted to enable ATP hydrolysis activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be part of GET complex. Is expressed in several structures, including Malpighian tubule primordium; adult head; dorsal ectoderm; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG1598 in Genome Data Viewer
Location:
43D3-43D3; 2-56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7538232..7539696, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3425737..3427201, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44209 Neighboring gene Cytochrome b5 Neighboring gene Glycerophosphate oxidase 2 Neighboring gene corin Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene boca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair. Nakamura M, et al. PLoS Genet, 2020 Dec. PMID 33306674, Free PMC Article
  2. Ultrasensitive proteome analysis using paramagnetic bead technology. Hughes CS, et al. Mol Syst Biol, 2014 Oct 30. PMID 25358341, Free PMC Article
  3. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Zou S, et al. Proc Natl Acad Sci U S A, 2000 Dec 5. PMID 11095759, Free PMC Article
  4. The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism. Pile LA, et al. J Biol Chem, 2003 Sep 26. PMID 12865422
  5. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, et al. Nat Chem Biol, 2015 May. PMID 25848931, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tail-anchored membrane protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GET complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1598-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7538232..7539696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136452.3 → NP_610296.2  uncharacterized protein Dmel_CG1598 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610296.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JWD3, Q8SZC0
    Related
    FBpp0088029
    Conserved Domains (2) summary
    COG0003
    Location:37 → 330
    ArsA; Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism]
    pfam02374
    Location:21 → 326
    ArsA_ATPase; Anion-transporting ATPase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWD3.1 Q7JWD3
Q8IH28 Q8IH28

Gene LinkOut

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