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fut-5 Alpha-(1,3)-fucosyltransferase fut-5 [ Caenorhabditis elegans ]

Gene ID: 3565968, updated on 28-Oct-2024

Summary

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Official Symbol
fut-5
Official Full Name
Alpha-(1,3)-fucosyltransferase fut-5
Primary source
WormBase:WBGene00043986
Locus tag
CELE_T05A7.10
See related
AllianceGenome:WB:WBGene00043986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Orthologous to several human genes including FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See fut-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (4665863..4667672, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene HMG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family. Nguyen K, et al. Glycobiology, 2007 Jun. PMID 17369288
  2. Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans. Paschinger K, et al. J Biol Chem, 2004 Nov 26. PMID 15364955
  3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables alpha-(1->3)-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in fucosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Alpha-(1,3)-fucosyltransferase fut-5
NP_001022310.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4665863..4667672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027139.2 → NP_001022310.1  Alpha-(1,3)-fucosyltransferase fut-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022310.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EE06
    Conserved Domains (2) summary
    pfam00852
    Location:179 → 361
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:51 → 159
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EE06.1

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