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hst-3.2 Sulfotransferase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3564879, updated on 18-Sep-2024

Summary

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Official Symbol
hst-3.2
Official Full Name
Sulfotransferase domain-containing protein
Primary source
WormBase:WBGene00044303
Locus tag
CELE_F52B10.2
See related
AllianceGenome:WB:WBGene00044303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi lumen. Is expressed in epithelial cell; hypodermis; neurons; and vulva. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; and pancreatic cancer. Orthologous to several human genes including HS3ST6 (heparan sulfate-glucosamine 3-sulfotransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See hst-3.2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (2918647..2923988, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Myosin-11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans. Tecle E, et al. G3 (Bethesda), 2013 Mar. PMID 23451335, Free PMC Article
  2. Direct visualization of specifically modified extracellular glycans in living animals. Attreed M, et al. Nat Methods, 2012 Apr 1. PMID 22466794, Free PMC Article
  3. Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans. Díaz-Balzac CA, et al. G3 (Bethesda), 2014 Aug 5. PMID 25098771, Free PMC Article
  4. The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans. Bhattacharya R, et al. J Cell Sci, 2009 Dec 15. PMID 19920077, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C. elegans HS 3-O-sulfotransferases hst-3.1 and hst-3.2 are dispensable for viability.
    Title: Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi lumen IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Sulfotransferase domain-containing protein
NP_001024698.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2918647..2923988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029527.3 → NP_001024698.1  Sulfotransferase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4TTA0
    Conserved Domains (1) summary
    pfam00685
    Location:29 → 281
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein
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