U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tsp42Ee Tetraspanin 42Ee [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35614, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Tsp42Eeprovided by FlyBase
Official Full Name
Tetraspanin 42Eeprovided by FlyBase
Primary source
FLYBASE:FBgn0029506
Locus tag
Dmel_CG10106
See related
AllianceGenome:FB:FBgn0029506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.151; BcDNA:LD16071; CG10106; Dm.Tsp42Ee; Dmel\CG10106
Summary
Located in fusome. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; presumptive embryonic/larval system; ventral midline of embryo; and yolk. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tsp42Ee in Genome Data Viewer
Location:
42E5-42E5; 2-55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7012254..7018362)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2899759..2905867)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ec Neighboring gene Tetraspanin 42Ed Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Immunoglobulin Superfamily Member Basigin Is Required for Complex Dendrite Formation in Drosophila. Shrestha BR, et al. Front Cell Neurosci, 2021. PMID 34803611, Free PMC Article
  2. The CD63 homologs, Tsp42Ee and Tsp42Eg, restrict endocytosis and promote neurotransmission through differential regulation of synaptic vesicle pools. Hendricks EL, et al. Front Cell Neurosci, 2022. PMID 36072568, Free PMC Article
  3. Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model. Linnemannstöns K, et al. J Extracell Vesicles, 2022 Sep. PMID 36103151, Free PMC Article
  4. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
  5. Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Beckett K, et al. Traffic, 2013 Jan. PMID 23035643, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tetraspanin 42Ee
Names
CG10106-PA
CG10106-PB
Tsp42Ee-PA
Tsp42Ee-PB
tetraspanin
tetraspanin 42E

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7012254..7018362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078907.3 → NP_523631.1  tetraspanin 42Ee, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523631.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJ73, Q8SY17
    Related
    FBpp0085512
    Conserved Domains (2) summary
    cd03127
    Location:106 → 187
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:8 → 219
    Tetraspannin; Tetraspanin family

  2. NM_001273824.1 → NP_001260753.1  tetraspanin 42Ee, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJ73, Q8SY17
    Conserved Domains (2) summary
    cd03127
    Location:106 → 187
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:8 → 219
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KJ73 Q7KJ73
Q8SY17 Q8SY17

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools