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chk chaski [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35578, updated on 18-Sep-2024

Summary

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Official Symbol
chkprovided by FlyBase
Official Full Name
chaskiprovided by FlyBase
Primary source
FLYBASE:FBgn0033095
Locus tag
Dmel_CG3409
See related
AllianceGenome:FB:FBgn0033095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3409; Chk; Dmel\CG3409
Summary
Enables monocarboxylic acid transmembrane transporter activity. Involved in monocarboxylic acid transport. Predicted to be integral component of membrane. Is expressed in several structures, including blastoderm embryo; embryonic/larval nervous system; extended germ band embryo; presumptive embryonic/larval system; and trunk ectoderm. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14); SLC16A4 (solute carrier family 16 member 4); and SLC16A6 (solute carrier family 16 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See chk in Genome Data Viewer
Location:
42C5-42C6; 2-55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6699695..6715892, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2587200..2603397, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene MOB kinase activator 4 Neighboring gene Rab2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43611 Neighboring gene mir-4975 stem loop Neighboring gene Zinc/iron regulated transporter-related protein 42C.1 Neighboring gene Zinc/iron regulated transporter-related protein 42C.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal lactate levels depend on glia-derived lactate during high brain activity in Drosophila. González-Gutiérrez A, et al. Glia, 2020 Jun. PMID 31876077
  2. Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress. Delgado MG, et al. Sci Rep, 2018 Jan 19. PMID 29352169, Free PMC Article
  3. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. Xu D, et al. PLoS Genet, 2023 Sep. PMID 37733679, Free PMC Article
  4. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
  5. A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation. Gándara L, et al. Sci Rep, 2019 Dec 27. PMID 31882718, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monocarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocarboxylic acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chaski
Names
CG3409-PA
CG3409-PB
CG3409-PC
chk-PA
chk-PB
chk-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6699695..6715892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169592.2 → NP_001163063.1  chaski, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T043, Q9V9B3
    Conserved Domains (1) summary
    cd06174
    Location:143 → 315
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_136386.4 → NP_610230.3  chaski, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610230.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T043, Q9V9B3
    Related
    FBpp0085473
    Conserved Domains (1) summary
    cd06174
    Location:143 → 315
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_001273804.1 → NP_001260733.1  chaski, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T043, Q9V9B3
    Conserved Domains (1) summary
    cd06174
    Location:143 → 315
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T043 Q8T043

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