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Pngl PNGase-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35527, updated on 2-Nov-2024

Summary

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Official Symbol
Pnglprovided by FlyBase
Official Full Name
PNGase-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0033050
Locus tag
Dmel_CG7865
See related
AllianceGenome:FB:FBgn0033050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7865; Dmel\CG7865; dNGLY1; ngly1; NGLY1; png1; Png1; PNGase; pngl
Summary
Enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Involved in positive regulation of BMP signaling pathway and visceral mesoderm-endoderm interaction involved in midgut development. Located in cytosol. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; gonad; imaginal disc; and larval central nervous system. Used to study congenital disorder of deglycosylation 1. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 1. Orthologous to human NGLY1 (N-glycanase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Pngl in Genome Data Viewer
Location:
42A7-42A8; 2-55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6017739..6020695)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1905244..1908200)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Src oncogene at 42A Neighboring gene Actin 42A Neighboring gene Ser/Thr-rich caspase Neighboring gene SREBP cleavage activating protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila. Pandey A, et al. Nat Commun, 2023 Sep 13. PMID 37704604, Free PMC Article
  2. Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency. Rodriguez TP, et al. G3 (Bethesda), 2018 Jul 2. PMID 29735526, Free PMC Article
  3. Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Owings KG, et al. Hum Mol Genet, 2018 Mar 15. PMID 29346549, Free PMC Article
  4. An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency. Hope KA, et al. PLoS Genet, 2022 Jun. PMID 35653343, Free PMC Article
  5. Evidence for an essential deglycosylation-independent activity of PNGase in Drosophila melanogaster. Funakoshi Y, et al. PLoS One, 2010 May 10. PMID 20479940, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoprotein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visceral mesoderm-endoderm interaction involved in midgut development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PNGase-like
Names
CG7865-PA
CG7865-PC
PNGase
Pngl-PA
Pngl-PC
NP_610192.1
NP_724444.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6017739..6020695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165454.3 → NP_724444.3  PNGase-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724444.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KRR5, Q8IGW3, Q8MRV8, Q9NBD5, Q9V9J5
    Conserved Domains (6) summary
    COG1305
    Location:282 → 378
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam01841
    Location:278 → 341
    Transglut_core; Transglutaminase-like superfamily
    pfam03835
    Location:325 → 383
    Rad4; Rad4 transglutaminase-like domain
    pfam04721
    Location:444 → 630
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    pfam09409
    Location:30 → 107
    PUB; PUB domain
    cl01498
    Location:98 → 185
    CitX; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

  2. NM_136348.3 → NP_610192.1  PNGase-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610192.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KRR5, Q8IGW3, Q8MRV8, Q9NBD5, Q9V9J5
    Related
    FBpp0085325
    Conserved Domains (6) summary
    COG1305
    Location:282 → 378
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam01841
    Location:278 → 341
    Transglut_core; Transglutaminase-like superfamily
    pfam03835
    Location:325 → 383
    Rad4; Rad4 transglutaminase-like domain
    pfam04721
    Location:444 → 630
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    pfam09409
    Location:30 → 107
    PUB; PUB domain
    cl01498
    Location:98 → 185
    CitX; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KRR5.1 Q7KRR5

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