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stw straw [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35494, updated on 18-Sep-2024

Summary

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Official Symbol
stwprovided by FlyBase
Official Full Name
strawprovided by FlyBase
Primary source
FLYBASE:FBgn0286203
Locus tag
Dmel_CG42345
See related
AllianceGenome:FB:FBgn0286203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10398; CG10408; CG30437; CG32838; CG42345; Dmel\CG42345; laccase2; Laccase2; MCO2; str
Old locus tag
Dmel_CG30437; Dmel_CG32838
Summary
Predicted to enable catechol oxidase activity and tyrosinase activity. Involved in chitin-based cuticle development. Is expressed in adult head. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin); HEPH (hephaestin); and HEPHL1 (hephaestin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See stw in Genome Data Viewer
Location:
41F1-41F1; 2-55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5413744..5456095)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1301249..1343600)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42646 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 50 member B3 Neighboring gene Troponin C isoform 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells. Ai Y, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35244715, Free PMC Article
  2. Inducible Expression of Eukaryotic Circular RNAs from Plasmids. Tatomer DC, et al. Methods Mol Biol, 2017. PMID 28766295
  3. Insect multicopper oxidases: diversity, properties, and physiological roles. Dittmer NT, et al. Insect Biochem Mol Biol, 2010 Mar. PMID 20219675
  4. The Beaded Minute combination and sex-determination in Drosophila. Sturtevant AH. Proc Natl Acad Sci U S A, 1949 Jun. PMID 16588895, Free PMC Article
  5. The Effect of Adult Body Color Mutations upon the Larva of Drosophila Melanogaster. Brehme KS. Proc Natl Acad Sci U S A, 1941 Jun 15. PMID 16588454, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 5417206-5417246 mobile_element_type = transposon:1360{}3623
  • Loc: 5421131-5421458 mobile_element_type = transposon:S{}665
  • Loc: 5424322-5424849 mobile_element_type = transposon:INE-1{}3226
  • Loc: 5424947-5424997 mobile_element_type = transposon:F{}3569
  • Loc: 5433449-5433947 mobile_element_type = transposon:INE-1{}3229
  • Loc: 5435080-5435129 mobile_element_type = transposon:INE-1{}3231
  • Loc: 5438373-5438471 mobile_element_type = transposon:Fw2{}3783
  • Loc: 5438666-5439216 mobile_element_type = transposon:INE-1{}3235
  • Loc: 5442603-5444659 mobile_element_type = transposon:Rt1b{}3599
  • Loc: 5444806-5446285 mobile_element_type = transposon:I{}3125
  • Loc: 5453071-5453132 mobile_element_type = transposon:INE-1{}4244

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catechol oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
straw
Names
CG42345-PA
CG42345-PD
CG42345-PE
CG42345-PF
CG42345-PG
Laccase-2
Laccase2
laccase
laccase 2
stw-PA
stw-PD
stw-PE
stw-PF
stw-PG
NP_001137606.1
NP_001260709.1
NP_610170.2
NP_724412.1
NP_724413.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5413744..5456095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136326.3 → NP_610170.2  straw, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610170.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6F4, Q86P50
    Conserved Domains (4) summary
    cd13858
    Location:230 → 333
    CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
    cd13884
    Location:352 → 500
    CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    cd13905
    Location:599 → 767
    CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    TIGR03388
    Location:230 → 775
    ascorbase; L-ascorbate oxidase, plant type

  2. NM_001273780.1 → NP_001260709.1  straw, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF30
    Conserved Domains (4) summary
    cd13858
    Location:230 → 333
    CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
    cd13884
    Location:352 → 500
    CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    cd13905
    Location:599 → 767
    CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    TIGR03388
    Location:230 → 775
    ascorbase; L-ascorbate oxidase, plant type

  3. NM_001144134.2 → NP_001137606.1  straw, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZT1, Q86P50
    Conserved Domains (4) summary
    cd13858
    Location:230 → 333
    CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
    cd13884
    Location:352 → 500
    CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    cd13905
    Location:599 → 767
    CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    TIGR03388
    Location:230 → 756
    ascorbase; L-ascorbate oxidase, plant type

  4. NM_165431.3 → NP_724412.1  straw, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQF6, Q86P50
    Related
    FBpp0289196
    Conserved Domains (4) summary
    cd13858
    Location:230 → 333
    CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
    cd13884
    Location:352 → 500
    CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    cd13905
    Location:599 → 767
    CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    TIGR03388
    Location:230 → 766
    ascorbase; L-ascorbate oxidase, plant type

  5. NM_165432.3 → NP_724413.2  straw, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724413.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6F6, Q86P50
    Conserved Domains (4) summary
    cd13858
    Location:195 → 298
    CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
    cd13884
    Location:317 → 465
    CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    cd13905
    Location:564 → 732
    CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
    TIGR03388
    Location:195 → 731
    ascorbase; L-ascorbate oxidase, plant type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF30 A0A0B4KF30
A1Z6F4 A1Z6F4
A1Z6F6 A1Z6F6
B7YZT1 B7YZT1
Q7JQF6 Q7JQF6
Q86P50 Q86P50

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