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CG42748 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35442, updated on 2-Nov-2024

Summary

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Official Symbol
CG42748provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261802
Locus tag
Dmel_CG42748
See related
AllianceGenome:FB:FBgn0261802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.28; CG15216; CG15217; CG6448; Dmel\CG42748
Old locus tag
Dmel_CG15216; Dmel_CG6448
Summary
Enables protein phosphatase 1 binding activity. Predicted to be involved in cell-cell junction organization. Located in lateral plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; epidermis; and ganglia. Orthologous to human AJM1 (apical junction component 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG42748 in Genome Data Viewer
Location:
40E5-40F2; 2-54 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22131221..22166221)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22131221..22166221)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43241 Neighboring gene Cyclin K Neighboring gene pseudo Neighboring gene disrupted underground network Neighboring gene long non-coding RNA:CR44809 Neighboring gene Chromatin-linked adaptor for MSL proteins Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. He B, et al. Nature, 2014 Apr 17. PMID 24590071, Free PMC Article
  2. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873
  3. Estimation of isolation times of the island species in the Drosophila simulans complex from multilocus DNA sequence data. McDermott SR, et al. PLoS One, 2008 Jun 18. PMID 18560591, Free PMC Article
  4. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343
  5. SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Rebeiz M, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12107285, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 22133546-22133845 mobile_element_type = transposon:S{}532
  • Loc: 22135450-22136081 mobile_element_type = transposon:Tc3{}2279
  • Loc: 22145280-22145514 mobile_element_type = transposon:INE-1{}6125
  • Loc: 22154099-22156468 mobile_element_type = transposon:INE-1{}6126
  • Loc: 22159423-22159478 mobile_element_type = transposon:INE-1{}6127
  • Loc: 22159968-22160009 mobile_element_type = transposon:INE-1{}6128
  • Loc: 22163258-22163806 mobile_element_type = transposon:INE-1{}6134

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lateral plasma membrane HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42748-PB
CG42748-PC
CG42748-PD
CG42748-PE
CG42748-PF
CG42748-PG
CG42748-PH
CG42748-PJ
CG42748-PK
CG42748-PL
CG42748-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22131221..22166221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273754.1 → NP_001260683.1  uncharacterized protein Dmel_CG42748, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260683.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBG0
    Conserved Domains (1) summary
    COG5422
    Location:1504 → 1678
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]

  2. NM_001103720.3 → NP_001097190.2  uncharacterized protein Dmel_CG42748, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097190.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY70
    Conserved Domains (1) summary
    pfam01753
    Location:1819 → 1850
    zf-MYND; MYND finger

  3. NM_001273755.1 → NP_001260684.1  uncharacterized protein Dmel_CG42748, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDE6
    Conserved Domains (1) summary
    pfam01753
    Location:1870 → 1901
    zf-MYND; MYND finger

  4. NM_001273757.1 → NP_001260686.1  uncharacterized protein Dmel_CG42748, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260686.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDL8

  5. NM_165411.3 → NP_724384.1  uncharacterized protein Dmel_CG42748, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9N7
    Related
    FBpp0292363

  6. NM_001103718.3 → NP_001097188.1  uncharacterized protein Dmel_CG42748, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ24

  7. NM_136290.4 → NP_610134.2  uncharacterized protein Dmel_CG42748, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610134.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9N7
    Related
    FBpp0292364
    Conserved Domains (1) summary
    PRK08853
    Location:955 → 1106
    PRK08853; DNA polymerase III subunits gamma and tau; Validated

  8. NM_001273756.1 → NP_001260685.1  uncharacterized protein Dmel_CG42748, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260685.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDY6
    Conserved Domains (2) summary
    pfam01753
    Location:502 → 533
    zf-MYND; MYND finger
    pfam16642
    Location:278 → 352
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  9. NM_001201933.1 → NP_001188862.1  uncharacterized protein Dmel_CG42748, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188862.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2VEE9, M9MSJ5

  10. NM_136292.2 → NP_610136.2  uncharacterized protein Dmel_CG42748, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610136.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9N5
    Conserved Domains (1) summary
    pfam01753
    Location:458 → 489
    zf-MYND; MYND finger

  11. NM_001103719.4 → NP_001097189.2  uncharacterized protein Dmel_CG42748, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097189.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ25
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DZ24 A8DZ24
A8DZ25 A8DZ25
M9MSJ5 M9MSJ5
M9PBG0 M9PBG0
M9PDE6 M9PDE6
M9PDL8 M9PDL8
M9PDY6 M9PDY6
Q9V9N5 Q9V9N5
Q9V9N7 Q9V9N7
R9PY70 R9PY70

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