RAMACL RNA guanine-7 methyltransferase activating subunit like [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAMACLprovided by HGNC
Official Full Name: RNA guanine-7 methyltransferase activating subunit likeprovided by HGNC
Primary source: HGNC:HGNC:21234
See related: Ensembl:ENSG00000235272 AllianceGenome:HGNC:21234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAMMETL; C6orf119; RAMMETP1; FAM103A2P; dJ427A4.2
Summary: Predicted to enable RNA binding activity. Predicted to be involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Predicted to be part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 6q27

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (166583009..166586678, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (167961081..167964751, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (166996497..167000166, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA 5'-cap (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of mRNA capping enzyme complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA guanine-N7 methyltransferase-activating subunit-like protein

Names: RNA guanine-7 methyltransferase activating subunit like (pseudogene); RNMT activating mRNA cap methyltransferase subunit like (pseudogene); RNMT activating mRNA cap methyltransferase subunit pseudogene 1; family with sequence similarity 103 member A2, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395999.1 → NP_001382928.1 RNA guanine-N7 methyltransferase-activating subunit-like protein

Status: VALIDATED

Source sequence(s)

Z98049

Consensus CDS

CCDS94031.1

UniProtKB/Swiss-Prot

A0A3B3IU46

Related

ENSP00000498060.1, ENST00000444122.3

Conserved Domains (1) summary

pfam15320
Location:10 → 87

RAM; mRNA cap methylation, RNMT-activating mini protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

166583009..166586678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

167961081..167964751 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001012240.1: Suppressed sequence

Description

NM_001012240.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.