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Lhfpl4 LHFPL tetraspan subfamily member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 353230, updated on 28-Oct-2024

Summary

Symbol
Lhfpl4provided by RGD
Full Name
LHFPL tetraspan subfamily member 4provided by RGD
Primary source
RGD:727967
See related
EnsemblRapid:ENSRNOG00000091268 AllianceGenome:RGD:727967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GABA receptor binding activity. Predicted to be involved in protein localization to membrane; regulation of inhibitory synapse assembly; and sensory perception of sound. Located in inhibitory synapse. Orthologous to human LHFPL4 (LHFPL tetraspan subfamily member 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 71.9) See more
Orthologs
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Genomic context

See Lhfpl4 in Genome Data Viewer
Location:
4q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147872877..147895770, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146317110..146340073, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145117533..145147397, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene SET domain containing 5 Neighboring gene transfer RNA proline (anticodon AGG) 26 Neighboring gene uncharacterized LOC134486623 Neighboring gene myotubularin related protein 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gamma-aminobutyric acid receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inhibitory synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inhibitory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
is_active_in inhibitory synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in inhibitory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
LHFPL tetraspan subfamily member 4 protein
Names
HMGIC fusion partner-like protein 4
lipoma HMGIC fusion partner-like 4 protein
lipoma HMGIC fusion partner-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181387.4NP_852052.3  LHFPL tetraspan subfamily member 4 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q7TSY2
    UniProtKB/TrEMBL
    A6IBP5
    Related
    ENSRNOP00000110268.1, ENSRNOT00000164144.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    147872877..147895770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)