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Caps2 calcyphosphine 2 [ Mus musculus (house mouse) ]

Gene ID: 353025, updated on 2-Nov-2024

Summary

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Official Symbol
Caps2provided by MGI
Official Full Name
calcyphosphine 2provided by MGI
Primary source
MGI:MGI:2441980
See related
Ensembl:ENSMUSG00000035694 AllianceGenome:MGI:2441980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D630005B03Rik
Summary
Predicted to enable calcium ion binding activity. Orthologous to human CAPS2 (calcyphosine 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 1.4), bladder adult (RPKM 0.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Caps2 in Genome Data Viewer
Location:
10 D2; 10 60.18 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111999254..112052466)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (112163349..112216561)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:111542860-111543160 Neighboring gene GLI pathogenesis-related 1 like 2 Neighboring gene STARR-seq mESC enhancer starr_27896 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene GLI pathogenesis-related 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_27897 Neighboring gene STARR-seq mESC enhancer starr_27898 Neighboring gene STARR-seq mESC enhancer starr_27899 Neighboring gene STARR-seq mESC enhancer starr_27901 Neighboring gene STARR-seq mESC enhancer starr_27902 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 2 Neighboring gene STARR-seq mESC enhancer starr_27903 Neighboring gene STARR-seq mESC enhancer starr_27905 Neighboring gene predicted gene, 40764

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Animal models of autism spectrum disorder (ASD): a synaptic-level approach to autistic-like behavior in mice. Shinoda Y, et al. Exp Anim, 2013. PMID 23615300
  2. Cloning, characterization, and expression of calcyphosine 2, a novel human gene encoding an EF-hand Ca(2+)-binding protein. Wang S, et al. Biochem Biophys Res Commun, 2002 Feb 22. PMID 11846421
  3. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Yagishita K, et al. Neurosci Lett, 2017 Nov 20. PMID 28963059
  4. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Mishima Y, et al. Sci Rep, 2015 Mar 10. PMID 25754523, Free PMC Article
  5. Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes. Sadakata T, et al. Neurosci Res, 2010 Jul. PMID 20302894

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
    Title: CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
  2. Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release
    Title: An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells.
  3. that CAPS2 deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons
    Title: CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus.
  4. These results suggest that Caps2 KO mice have altered endocrine responses to CORT administration, while maintaining CORT-induced anxiety/depressive-like behavior.
    Title: Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice.
  5. Naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 primes vesicles independently of its MUN domain.
    Title: Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.
  6. possible association of the dense-core vesicle secretion-related gene,CAPS2 with autism specturum disorder. (review)
    Title: Animal models of autism spectrum disorder (ASD): a synaptic-level approach to autistic-like behavior in mice.
  7. CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
    Title: Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
  8. CAPS2 promotes activity-dependent brain-derived neurotrophic factor secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.
    Title: Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.
  9. CAPS2 KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders
    Title: Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes.
  10. The CAPS2-deficient mice show reduced secretion of BDNF and NT-3. And the cerebella of these mice exhibit developmental deficits, such as delayed development.
    Title: Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
calcyphosin-2
Names
calcyphosine 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310675.1 → NP_001297604.1  calcyphosin-2 isoform 2

    See identical proteins and their annotated locations for NP_001297604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC166263, AK085286
    Consensus CDS
    CCDS78896.1
    UniProtKB/Swiss-Prot
    E9Q2J8, G3X9M5, Q8BUG5, Q8C1J6
    UniProtKB/TrEMBL
    Q0VG46
    Related
    ENSMUSP00000089815.2, ENSMUST00000092176.8

  2. NM_178278.4 → NP_840062.2  calcyphosin-2 isoform 1

    See identical proteins and their annotated locations for NP_840062.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK015008, AK085286
    Consensus CDS
    CCDS24172.2
    UniProtKB/TrEMBL
    Q0VG46
    Related
    ENSMUSP00000129887.2, ENSMUST00000170013.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    111999254..112052466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513814.4 → XP_006513877.1  calcyphosin-2 isoform X3

    See identical proteins and their annotated locations for XP_006513877.1

    UniProtKB/TrEMBL
    Q0VG46
    Conserved Domains (1) summary
    pfam13499
    Location:426 → 488
    EF-hand_7; EF-hand domain pair

  2. XM_006513815.1 → XP_006513878.1  calcyphosin-2 isoform X3

    See identical proteins and their annotated locations for XP_006513878.1

    UniProtKB/TrEMBL
    Q0VG46
    Conserved Domains (1) summary
    pfam13499
    Location:426 → 488
    EF-hand_7; EF-hand domain pair

  3. XM_006513816.1 → XP_006513879.1  calcyphosin-2 isoform X3

    See identical proteins and their annotated locations for XP_006513879.1

    UniProtKB/TrEMBL
    Q0VG46
    Conserved Domains (1) summary
    pfam13499
    Location:426 → 488
    EF-hand_7; EF-hand domain pair

  4. XM_036155868.1 → XP_036011761.1  calcyphosin-2 isoform X1

    UniProtKB/TrEMBL
    Q0VG46

  5. XM_011243499.1 → XP_011241801.1  calcyphosin-2 isoform X1

    See identical proteins and their annotated locations for XP_011241801.1

    UniProtKB/TrEMBL
    Q0VG46

  6. XM_006513818.1 → XP_006513881.1  calcyphosin-2 isoform X5

    UniProtKB/TrEMBL
    Q0VG46

  7. XM_006513817.4 → XP_006513880.1  calcyphosin-2 isoform X4

    UniProtKB/TrEMBL
    Q0VG46

  8. XM_006513813.4 → XP_006513876.1  calcyphosin-2 isoform X2

    UniProtKB/TrEMBL
    Q0VG46

  9. XM_006513820.4 → XP_006513883.1  calcyphosin-2 isoform X6

    UniProtKB/TrEMBL
    Q0VG46
    Conserved Domains (1) summary
    pfam13499
    Location:446 → 508
    EF-hand_7; EF-hand domain pair

  10. XM_006513821.4 → XP_006513884.1  calcyphosin-2 isoform X7

  11. XM_006513822.5 → XP_006513885.1  calcyphosin-2 isoform X8

RNA

  1. XR_380413.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUG5.2 GenPept UniProtKB/Swiss-Prot:Q8BUG5

Gene LinkOut

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