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CTSC cathepsin C [ Bos taurus (domestic cattle) ]

Gene ID: 352958, updated on 17-Aug-2024

Summary

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Official Symbol
CTSCprovided by VGNC
Official Full Name
cathepsin Cprovided by VGNC
Primary source
VGNC:VGNC:27814
See related
BGD:BT28669; Ensembl:ENSBTAG00000011100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 29
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (7375381..7415746)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444873 Neighboring gene histone H2B type 1-K Neighboring gene uncharacterized LOC104976218 Neighboring gene RAB38, member RAS oncogene family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cathepsin H is an additional convertase of pro-granzyme B. D'Angelo ME, et al. J Biol Chem, 2010 Jul 2. PMID 20435891, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC126959

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dipeptidyl peptidase 1
Names
DPP-I
DPPI
cathepsin J
dipeptidyl peptidase I
dipeptidyl transferase
NP_001028789.1
XP_010819111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033617.2 → NP_001028789.1  dipeptidyl peptidase 1 precursor

    See identical proteins and their annotated locations for NP_001028789.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102115
    UniProtKB/Swiss-Prot
    Q3ZCJ8
    UniProtKB/TrEMBL
    Q864S1
    Related
    ENSBTAP00000014735.4, ENSBTAT00000014735.6
    Conserved Domains (2) summary
    cd02621
    Location:231 → 460
    Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
    pfam08773
    Location:26 → 138
    CathepsinC_exc; Cathepsin C exclusion domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    7375381..7415746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010820809.4 → XP_010819111.1  dipeptidyl peptidase 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T2L4
    Related
    ENSBTAP00000091973.1, ENSBTAT00000127306.1
    Conserved Domains (1) summary
    pfam08773
    Location:26 → 106
    CathepsinC_exc; Cathepsin C exclusion domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZCJ8.1 GenPept UniProtKB/Swiss-Prot:Q3ZCJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials