sNPF short neuropeptide F precursor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sNPFprovided by FlyBase
Official Full Name: short neuropeptide F precursorprovided by FlyBase
Primary source: FLYBASE:FBgn0032840
Locus tag: Dmel_CG13968
See related: AllianceGenome:FB:FBgn0032840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38B.2; CG13968; Dmel\CG13968; Drm-sNPF; Drm-sNPF-1; Drm-sNPF-2; Drm-sNPF-3; Drm-sNPF-4; Drm-sNPF-AP1; lrlrfa; LRLRFamide; s-NPF; short NPF; snpf; SNPF; sNPF-1; sNPF-1[4-11]; sNPF-2; sNPF-2s; sNPF-2[12-19]; sNPF-3; sNPF-4; sNPF1; sNPF1[1-11]; sNPF1[4-11; sNPF2[12-19]; sNPF3
Summary: Enables neuropeptide hormone activity and neuropeptide receptor binding activity. Involved in several processes, including adult feeding behavior; larval feeding behavior; and regulation of cellular carbohydrate metabolic process. Located in axon; extracellular space; and neuronal cell body. Is expressed in several structures, including endocrine system component; gut section; nervous system; sense organ; and ventral midline of embryo. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 38B1-38B1; 2-54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20027915..20056373)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20027915..20056373)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results provide supportive evidence that sNPF-producing neurons promote long-lasting increases in sleep, and show for the first time that even brief periods of activation of these neurons can cause changes in behavior that persist after cessation of activation.
Title: Optogenetic activation of short neuropeptide F (sNPF) neurons induces sleep in Drosophila melanogaster.
Light and the neuropeptides PDF and sNPF act dynamically at distinct hubs of the circadian neural circuit to produce multiple suppressive events that create the proper tempo and sequence of circadian pacemaker neuronal activities.
Title: A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs.
Findings indicate that short neuropeptide F (sNPF) and corazonin (CRZ) co-released from a small set of neurons regulate insulin-producing cells (IPCs) stress resistance and metabolism.
Title: Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.
Loss of function of sNPF and sNPFR1 also elevated sleep.
Title: Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster.
Here we show that a neuropeptide precursor gene encoding four types of short neuropeptide F (sNPF) is required in the Kenyon cells for appetitive olfactory memory.
Title: Short neuropeptide F acts as a functional neuromodulator for olfactory memory in Kenyon cells of Drosophila mushroom bodies.
Different layers of the fan-shaped body sNPFR1
Title: Distribution of metabotropic receptors of serotonin, dopamine, GABA, glutamate, and short neuropeptide F in the central complex of Drosophila.
We have demonstrated here that subsets of Drosophila lateral clock neurons are heterogeneous with respect to expression of neuroactive compounds, including ion transport peptide and short neuropeptide F
Title: Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons.
These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila.
Title: Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster.
Data show Drosophila brain expressing short neuropeptide F transcript and short neuropeptide F peptide. Most of these
Title: A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions.
Results show that Drosophila short neuropeptide F, an orthologue of mammalian neuropeptide Y, and sNPF receptor sNPFR1 regulate expression of insulin-like peptides.
Title: Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to food	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short neuropeptide F precursor

Names: CG13968-PB; LRLRFamides; SMALL NEUROPEPTIDE F; neuropeptide F (short); precursor of short neuropeptide F; sNPF precursor; sNPF-PB; short NPF; short neuropeptide F; short neuropeptide F-1; short neuropeptide F1; small neuropeptide F-1; small neuropeptide-F