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fbp fructose-1,6-bisphosphatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35265, updated on 2-Nov-2024

Summary

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Official Symbol
fbpprovided by FlyBase
Official Full Name
fructose-1,6-bisphosphataseprovided by FlyBase
Primary source
FLYBASE:FBgn0032820
Locus tag
Dmel_CG31692
See related
AllianceGenome:FB:FBgn0032820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10611; CG31692; Dmel\CG31692; Fbp; FbPase
Summary
Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval crystal cell; larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See fbp in Genome Data Viewer
Location:
38A2-38A3; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19761587..19764136, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19761587..19764136, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 3 Neighboring gene brain-specific homeobox Neighboring gene Cd GTPase activating protein-related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster. Chambers MC, et al. PLoS One, 2012. PMID 23272066, Free PMC Article
  2. Organically grown food provides health benefits to Drosophila melanogaster. Chhabra R, et al. PLoS One, 2013. PMID 23326371, Free PMC Article
  3. Fructose-1,6-bisphosphatase genes in animals. Tillmann H, et al. Gene, 2002 May 29. PMID 12095679
  4. Honeybee queen mandibular pheromone induces a starvation response in Drosophila melanogaster. Lovegrove MR, et al. Insect Biochem Mol Biol, 2023 Mar. PMID 36657589
  5. Neuronal Gluconeogenesis Regulates Systemic Glucose Homeostasis in Drosophila melanogaster. Miyamoto T, et al. Curr Biol, 2019 Apr 22. PMID 30930040

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c19763048-19762862 mobile_element_type = transposon:pogo{}421

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose 1,6-bisphosphate 1-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fructose-1,6-bisphosphatase
Names
CG31692-PA
CG31692-PC
CG31692-PD
CG31692-PF
fbp-PA
fbp-PC
fbp-PD
fbp-PF
NP_001286090.1
NP_001286091.1
NP_610001.1
NP_724223.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19761587..19764136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299161.1 → NP_001286090.1  fructose-1,6-bisphosphatase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286090.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JES1
    Conserved Domains (1) summary
    cd00354
    Location:7 → 321
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

  2. NM_136157.3 → NP_610001.1  fructose-1,6-bisphosphatase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610001.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT33, Q9VIS3
    Related
    FBpp0080853
    Conserved Domains (1) summary
    cd00354
    Location:19 → 333
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

  3. NM_001299162.1 → NP_001286091.1  fructose-1,6-bisphosphatase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JES1
    Conserved Domains (1) summary
    cd00354
    Location:7 → 321
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

  4. NM_165314.2 → NP_724223.4  fructose-1,6-bisphosphatase, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0U1RVK6, C6SV43
    Conserved Domains (1) summary
    cd00354
    Location:28 → 342
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0U1RVK6 A0A0U1RVK6
Q9VIS3 Q9VIS3
X2JES1 X2JES1

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